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This article explores the conditions under which epistemic breakthrough innovation is possible, in the light of the determinations likely to emerge from the systems mobilized, constituting an innovation that is a source of managerial transformations that will themselves be described as innovative. The article contributes to the clarification of the concept of "enantiological transformation," showing it to be the spatial and foundational substructure of innovation and, more broadly, of change. The research is carried out as part of a research-intervention assignment within a consortium of agricultural cooperatives. Its purpose is to study the opportunity and feasibility of merging thirteen agricultural cooperatives due to their local competitive stalemate and financial deficits. These deficits are the result of the structural economic and financial crises in their sectors, which were exacerbated by the economic crisis of 2008. The thesis is that the development of business strategies, including their teaching, is still very much the subject of epistemological servitude. This restricts creative and innovative thinking.