Digital technology has become integral in the fields of health and care, and a number of recent reports have stressed the importance of equipping health and care staff with the skills and knowledge they need to use such technology effectively. Numerous failures of digital projects in the health and care sectors have demonstrated that simply relocating IT generalists into these specialist fields is not a guaranteed formula for success; the unique complexities of the typically under-resourced legacy infrastructures of health and care create challenges that demand specific education and training. This book presents the proceedings of the European Federation for Medical Informatics (EFMI) 2022 Special Topic Conference (STC), held in Cardiff, Wales, on 7-8 September 2022. The theme of STC 2022 was Digital Professionalism in Health and Care: Developing the Workforce, Building the Future, which emphasized the vital need for professional education, training and continuing development of the health and care informatics workforce. The 30 full papers and 5 posters in this book cover a broad range of topics and methods in informatics education and training, and include a small selection from the wider sub-domains of biomedical informatics. Providing a valuable overview of current methods and training, the book will be of interest to a wide range of professionals working in healthcare today, especially those involved in equipping the workforce with the skills they will need for the digital future.