Personalized health technologies offer many benefits. Smart mobile systems, textiles and implants and sensor-controlled medical devices have become important enablers for telemedicine and ubiquitous pervasive health as the next-generation health services, while social media and gamification have added another dimension to pHealth as an eco-system. This book presents the proceedings of pHealth 2022, the 19th in the conference series, held as a hybrid event in Oslo, Norway, from 8 – 10 November 2022. The pHealth 2022 conference attracted experts from many scientific domains and brought together health-service vendor and provider institutions, payer organizations, government departments, academic institutions, professional bodies, and patients and citizen representatives. Topics covered include mobile technologies, micro-nano-bio smart systems, bio-data management and analytics, machine learning, artificial intelligence and robotics for personalized health, the Health Internet of Things (HIoT), systems medicine, public health and virtual care. The book includes 2 keynote papers, 10 invited papers, 20 full papers, and 4 poster papers by 113 authors from 23 countries. All submissions were carefully and critically reviewed by at least two independent experts from a country other than the author’s home country, and additionally by at least one member of the Scientific Program Committee, guaranteeing a high scientific level of the accepted and ultimately published papers. Exploring the enormous potential of pHealth for improvements in medical quality and also for the management of healthcare costs and the provision of a better patient experience, the book will be of interest to all those involved in the development and provision of healthcare.