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The Human Proteome Project (HPP) is an international project that aims to revolutionize our understanding of the human proteome through a coordinated effort by numerous research laboratories around the world. It has been structured into two branches: the C-HPP, organized into as many groups as there are human chromosomes; and the B/D-HPP, organized into initiatives whose main goal is to apply proteome analysis technologies to better understand the molecular mechanisms that underlie physiological and pathophysiological processes. The two main objectives of the HPP are to establish a comprehensive inventory of proteins encoded by the human genome and to characterize the functions of these proteins and their numerous proteoforms. In this mini review, we will discuss the state of progress of the HPP, the upcoming project (called HPP Grand Challenge), and the value of participating in this new endeavor for the community of researchers and clinicians in reproductive biology.