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Neonatal infection with Salmonella typhimurium is rare and can have variable clinical aspects up to severe and often fatal sepsis. The objective of this study is to investigate the clinical, bacteriological, and evolutionary aspects of neonatal infection with extended-spectrum beta-lactamase (ESBL+) producing S. typhimurium through a three-year retrospective study including five observations. All the cases were from the same provincial hospital. The mean age was sixteen days. The main symptomatology was related to acute dehydration. The bacteriological workup showed S. typhimurium ESBL+ in all cases. The therapeutic treatment was based on antibiotic therapy adapted to the antibiogram, combined with symptomatic treatment. The evolution was favorable in four cases and fatal in one case following sepsis. Although third-generation cephalosporins are the standard form of treatment, the emergence of more and more resistant strains makes it essential to adapt the antibiotic therapy to the antibiogram of the isolated germ.