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Decision-making is a complex human activity that uses a set of cognitive and emotional processes linked to the integrity of prefrontal cortex. This paper reviews what we currently know about the link between decision-making and frontal symptomatology. Also discussed are the results of neuroimaging studies of decision-making. More precisely, the impact of focal frontal lobe lesions, obsessive-compulsive disorder, and schizophrenia on decision-making are explored. This analysis showed inhomogeneous results, both for neurological and psychiatric studies. This calls for further investigation of decision-making skills, which will be necessary to compare patients’ performance in decision-making tasks and functional outcomes, in order to explore the ecological validity of the assessment tools.