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Today, many highly qualified women, with specializations in traditional or innovative areas, are found working as consultants, assistants or selfemployed professionals: their fragmented career paths include going back and forth between different places where and from which they work. In this context, the home is one of the working spaces, where new opportunities and old contradictions can be found. The desire for autonomy and the satisfaction of using one’s own skills to create ideas and projects that find their place in the labor market coexist with the need for unlimited investment on many fronts in terms of time and personal commitment that does not preclude the feeling of isolation and solitude. Teleworking and the intensive use of technological means create the feeling of “working without a body”. The article sheds light on “emptiness and fullness” with regard to corporality and highlights the “dematerialization effects” that occur within the organization of “remote” work, especially when it is carried out in the domestic space. In terms of methodology, the use of a biographical and narrative approach made it possible to understand the experiences of the women interviewed based on the meaning they themselves give to their own work experiences and their unique position in the domestic space.