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In the last 30 years, the accumulation of new interdisciplinary evidence about the properties, time course, and outcome of early crying, including the clinical manifestations of “colic,” has changed our understanding of crying. It is no longer viewed as a behavior that is considered abnormal or indicative of disease or dysfunction in the infant, the parents, or both and is now viewed as a behavior that is part and parcel of normal human infant development. This also implies that the socio-emotional consequences of crying largely depend on how caregivers interpret and respond to crying. These responses may have long-term effects both in terms of how they treat the infant, on the one hand, and whether they consider that they are poor parents if they cannot soothe their infant or handle the crying, on the other [5, 6, 40, 47–54]. However, in the absence of other compromises in the infant or its environment, the outcome for infants with early increased crying or colic is good.