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The Developmental and Sequenced One-to-one Educational Intervention (DS1-EI) is a pedagogical tool for children on the autistic spectrum or with an intellectual disability, aiming to base their developmental process of subjectivation on a school mediation program. This soothing and ritualized setting meets the needs of these children, as well as the expectations of institutions and teams who wish to use structured tools in the context of individual integrative care. The Developmental and Sequenced One-to-one Educational Intervention (DS1-EI) was tested by a randomized controlled clinical trial between 2013 and 2017. This article presents the principles and supports of the system, the research protocol, as well as the final results that were published in international papers.