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Through this article we will examine some points of this vast research topic that concerns subjects and the contemporary social bond: the concept of “subject,” and more precisely the subject of the unconscious; knotting modalities, from the subject’s structure to the nature of the social bond; and finally the symptom and the contemporary social bond, testing the psychoanalytical assumption that subjects tie themselves to society through the symptom. We will show how Freud, and then Lacan, tried to overcome the binary opposition between individual and social, and we will question the impact of the emergence of the market economy, liberalism, and globalization on the subject of the unconscious and on current psychopathology. We will interrogate the relationship between the subject and the social bond, the way subjects tie themselves to other subjects in the “living together” from the family to the social and political community, and the way subjects resist new social imperatives. Throughout our discussion, we will refer to the insights of psychoanalysis, psychopathology and of the major changes relating to the new family and social configurations.