Triple-negative breast cancer: From biology to clinical practice
Type de matériel :
TexteLangue : français Détails de publication : 2022.
Ressources en ligne : Abrégé : Triple-negative breast cancers (TNBC) are a large heterogeneous group of pathological and biologically diverse carcinomas. TNBC may be categorized based on distinct genomic or transcriptional patterns and/or immune characteristics, and classified as basal-like, mesenchymal, and luminal androgen-receptor subtypes. They may be highly infiltrated by immune cells or devoid of them. Molecular alterations should be screened to help define the treatment. Thus, there is a need to adopt a comprehensive view of TNBC biology in order to tailor the therapeutic strategy with targeted agents, including novel antibody-drug conjugates or innovative immunotherapies.
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Triple-negative breast cancers (TNBC) are a large heterogeneous group of pathological and biologically diverse carcinomas. TNBC may be categorized based on distinct genomic or transcriptional patterns and/or immune characteristics, and classified as basal-like, mesenchymal, and luminal androgen-receptor subtypes. They may be highly infiltrated by immune cells or devoid of them. Molecular alterations should be screened to help define the treatment. Thus, there is a need to adopt a comprehensive view of TNBC biology in order to tailor the therapeutic strategy with targeted agents, including novel antibody-drug conjugates or innovative immunotherapies.
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