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This article is based on a unique and emblematic case study. It aims to investigate and analyze the dimensions of the resilience of a humanitarian supply chain in the face of a major crisis such as that of Covid-19. Our main question can be formulated as follows: What are the major characteristics that make a humanitarian supply chain resilient? Our results offered a conceptual framework with four dimensions: reorganization capacity, collaboration, agility, and humanitarian culture. To be deployed, these dimensions require both proactive and reactive actions. These actions are presented in this article. There are two main factors that explain this resilience: its information system (IS) (robustness, transversality, agility) and its humanitarian culture.