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Chemsex refers to the use of psychoactive substances to initiate, facilitate, prolong, or enhance sexual intercourse. The practice mainly concerns men who have sex with men (MSM). In France, these substances are mainly represented by synthetic cathinones and gamma-hydroxybutyrate (GHB). Over the past ten years, the practice has become increasingly visible and widespread, thanks to the internet and the advent of location-based dating apps. Numerous complications are associated with this practice and have been extensively described, but sexual health is rarely addressed. We have therefore studied the impact of chemsex on users’ quality of life and sexual satisfaction. Methods. Observational study. During consultations, those attending for chemsex use were asked to complete the Male Sexual Health Questionnaire (MSHQ). Socio-demographic data and information on modes of practice were also collected. Results. Twenty-two participants were interviewed, with a median age of thirty-six years. Median scores revealed erectile and especially ejaculatory disturbances, with median scores of 13/15 and 28/35 respectively. The scores for erectile and ejaculatory discomfort also point in this direction. This finding once again highlights the impact of chemsex substances and practice on sexual-health quality of life, and the need to develop questionnaires tailored to this user population.