Analysis of vascular endothelial growth factor (VEGF) insertion/deletion gene polymorphism and environmental risk factors in a sample of the Algerian population with neovascular age-related macular degeneration (nAMD)
Abid, Ghania
Analysis of vascular endothelial growth factor (VEGF) insertion/deletion gene polymorphism and environmental risk factors in a sample of the Algerian population with neovascular age-related macular degeneration (nAMD) - 2022.
57
Background: Increasing evidence shows that genetic and environmental factors can influence the risk of neovascular age-related macular degeneration (nAMD). Objective: The aim of this study was first to analyze the association of insertion/deletion polymorphism in the VEGF gene and environmental factors with the risk of nAMD, and then to investigate whether these factors have an impact on the age of onset of nAMD in a sample of the Algerian population. Methods: Seventy-two patients with nAMD and 124 controls were recruited. A standardized questionnaire was used to collect information about underlying systemic diseases and important environmental factors. Genotyping of VEGF (I/D) SNP was conducted using a PCR-based assay approach, and statistical analyses were conducted using IBM SPSS Statistics 21. Results: A significant association was reported between nAMD and age (p < 0.05), smoking (p = 0.02), alcohol (p < 0.01), hypertension (p = 0.04), hyperlipidemia (p = 0.008), and thyroid disease (p = 0.03). Additionally, thyroid disease may play a role in accelerating the development of nAMD at an earlier age in our sample (p < 0.001). No association was found between the VEGF – 2549 I/D genotype and the presence of nAMD (p = 0.27), or with the age of onset of nAMD (p = 0.21). Conclusion: Our results suggest that age, smoking, alcohol, hypertension, hyperlipidemia, and thyroid diseases are possible risk factors that could increase the risk of nAMD in a sample of the Algerian population. In addition, VEGF – 2549 I/D might not be associated with the risk of nAMD development. Finally, thyroid disease may accelerate the development of nAMD at an earlier age.
Analysis of vascular endothelial growth factor (VEGF) insertion/deletion gene polymorphism and environmental risk factors in a sample of the Algerian population with neovascular age-related macular degeneration (nAMD) - 2022.
57
Background: Increasing evidence shows that genetic and environmental factors can influence the risk of neovascular age-related macular degeneration (nAMD). Objective: The aim of this study was first to analyze the association of insertion/deletion polymorphism in the VEGF gene and environmental factors with the risk of nAMD, and then to investigate whether these factors have an impact on the age of onset of nAMD in a sample of the Algerian population. Methods: Seventy-two patients with nAMD and 124 controls were recruited. A standardized questionnaire was used to collect information about underlying systemic diseases and important environmental factors. Genotyping of VEGF (I/D) SNP was conducted using a PCR-based assay approach, and statistical analyses were conducted using IBM SPSS Statistics 21. Results: A significant association was reported between nAMD and age (p < 0.05), smoking (p = 0.02), alcohol (p < 0.01), hypertension (p = 0.04), hyperlipidemia (p = 0.008), and thyroid disease (p = 0.03). Additionally, thyroid disease may play a role in accelerating the development of nAMD at an earlier age in our sample (p < 0.001). No association was found between the VEGF – 2549 I/D genotype and the presence of nAMD (p = 0.27), or with the age of onset of nAMD (p = 0.21). Conclusion: Our results suggest that age, smoking, alcohol, hypertension, hyperlipidemia, and thyroid diseases are possible risk factors that could increase the risk of nAMD in a sample of the Algerian population. In addition, VEGF – 2549 I/D might not be associated with the risk of nAMD development. Finally, thyroid disease may accelerate the development of nAMD at an earlier age.
Réseaux sociaux