Y a-t-il une place pour la stimulation cérébrale profonde dans le traitement symptomatique de la maladie d'Alzheimer ? (notice n° 1027996)
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| fixed length control field | 04750cam a2200337 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250125171715.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Fontaine, Denys |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Y a-t-il une place pour la stimulation cérébrale profonde dans le traitement symptomatique de la maladie d'Alzheimer ? |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2012.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 59 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | RésuméLes traitements symptomatiques de la maladie d’Alzheimer (MA) sont relativement décevants. Récemment, deux études ont montré pour la première fois qu’il était possible d’améliorer les performances mnésiques chez l’homme par stimulation électrique des réseaux impliqués dans la mémoire. Une amélioration mnésique a été observée fortuitement après stimulation cérébrale profonde (SCP) du fornix, dans l’hypothalamus, chez un patient traité initialement pour obésité morbide. Chez des patients épileptiques explorés par électrodes profondes, la mémorisation spatiale a été améliorée par l’application d’une stimulation électrique du cortex entorhinal. Des données électrophysiologiques et des observations chez l’animal suggèrent plusieurs mécanismes d’action : augmentation de la neurogenèse hippocampique, réactivation du rythme thêta, potentialisation à long terme et réactivation de régions néocorticales hypoactives. Deux études suggèrent que la SCP pourrait moduler ces circuits mnésiques chez des patients avec troubles cognitifs. Dans une étude pilote, la SCP du fornix a stabilisé ou ralenti le déclin cognitif chez quelques patients atteints de MA. Dans une autre étude, la stimulation du noyau basal de Meynert d’un patient parkinsonien dément a amélioré certaines capacités mnésiques, attentionnelles et praxiques. Ces données font naître l’espoir d’un nouveau traitement symptomatique de la MA mais soulèvent de nombreuses questions : quels patients ?, à quel stade ?, pour quel bénéfice ? |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Is there a future for deep brain stimulation as a symptomatic treatment in Alzheimer’s disease ?Benefit from symptomatic and etiologic treatments in Alzheimer’s disease (AD) are still insufficient. Recently two studies demonstrated that electrical stimulation of memory circuits can enhance memory in humans without memory impairment. First, improvement of verbal recollection has been reported after deep brain stimulation (DBS) of the fornix in the hypothalamus, in a patient in which DBS was implanted to treat morbid obesity. More recently, seven epileptic patients explored by deep electrodes underwent spatial learning tasks. When electrical stimulation of the entorhinal cortex was applied during the learning phase, they improved significantly their visuo-spatial performances during the test phase, compared to non-stimulated controls. Animal studies, electrophysiological and metabolic data suggest several mechanisms of action: resetting of hippocampal theta phase, increase of hipocampal neurogenesis, enhanced long term potentiation, diffuse reactivation of hypoactive neo-cortical associative regions belonging to the brain default network. Two studies suggest that DBS could be used to modulate memory circuits in patients with cognitive decline. In a phase I study, chronic DBS of the fornix achieved to stabilize or slow the memory decline of few patients with mild AD, one year after surgery. Another pilot study reported a reversible improvement of memory, apraxia and alertness in a patient with Parkinson dementia treated by DBS of the nucleus basalis of Meynert (NBM). These data suggest that DBS could be used as a symptomatic treatment of memory impairment in patients with dementia, but also rise numerous questions that are discussed here: Which patients will be best candidates for surgery, considering the benefit/risk ratio of DBS? Which target (fornix, NBM, entorhinal cortex) will be the best one, considering that they undergo a degenerating process during AD ? How sustainable will be the benefit of DBS ? What will be the acceptation of DBS by AD patients ? |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | circuit de Papez |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | fornix |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | neuromodulation |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | stimulation cérébrale profonde |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | recherche clinique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Alzheimer |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Papez circuit |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | fornix |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | clinical trial |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | neuromodulation |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | deep brain stimulation |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Alzheimer |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Deudon, Audrey |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Robert, Philippe |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Revue de neuropsychologie | Volume 4 | 2 | 2012-04-01 | p. 108-113 | 2101-6739 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-de-neuropsychologie-2012-2-page-108?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-de-neuropsychologie-2012-2-page-108?lang=fr&redirect-ssocas=7080</a> |
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