Réserve cérébrale et réserve cognitive dans la maladie d’Alzheimer : l’apport des modèles murins (notice n° 1028179)
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| fixed length control field | 03141cam a2200325 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250125171751.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Bezzina, Charlotte |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Réserve cérébrale et réserve cognitive dans la maladie d’Alzheimer : l’apport des modèles murins |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2014.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 21 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Le concept de réserve cognitive et cérébrale permet d’expliquer l’inadéquation parfois observée entre le niveau d’atteinte cérébrale et les performances cognitives d’individus atteints de la maladie d’Alzheimer. Cette réserve, dont l’établissement reposerait sur l’engagement régulier dans des activités éducatives ou de loisirs, diminuerait le risque de démence de type Alzheimer. Dans le but d’identifier les substrats neurobiologiques qui sous-tendent cette réserve, le modèle murin est largement utilisé. En effet, des souris transgéniques modèles de la maladie d’Alzheimer présentent, après exposition à un milieu enrichi, une progression ralentie de la pathologie, mesurable aux niveaux cognitif et anatomique. Le paradigme d’enrichissement environnemental semble donc adapté à l’étude des processus cérébraux impliqués dans l’expression de la réserve cognitive. Des études récentes ont analysé ces processus aux niveaux cellulaire et moléculaire, et suggèrent notamment l’implication des nouveaux neurones hippocampiques produits dans le cerveau adulte. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Brain reserve and cognitive reserve in Alzheimer's disease: lessons from murine modelsThe concept of cognitive and neural reserve has been used to account for the discrepancy between the degree of brain damage and cognitive performances of Alzheimer's disease (AD) patients. This reserve, built on regular participation in educational or leisure activities, has been linked to a reduced risk of AD-related pathology. In order to identify the neurobiological substrates underlying this reserve, murine models have largely been used. Indeed, AD transgenic mice models exhibit, after environmental enrichment exposure, a delayed progression of the pathology, measurable at both cognitive and anatomical levels. Thus, the environmental enrichment paradigm seems to be appropriate to study neural processes involved in the cognitive reserve. Recent studies have analyzed these processes at the cellular and molecular levels, suggesting in particular, that hippocampal adult neurogenesis could be involved. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | enrichissement environnemental |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | mémoire |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | neurogenèse adulte |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | souris transgéniques |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | activité physique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | hippocampe |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | hippocampus |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | memory |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | transgenic mice |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | environmental enrichment |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | adult neurogenesis |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | physical activity |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rampon, Claire |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Revue de neuropsychologie | Volume 5 | 4 | 2014-01-01 | p. 293-297 | 2101-6739 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-de-neuropsychologie-2013-4-page-293?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-de-neuropsychologie-2013-4-page-293?lang=fr&redirect-ssocas=7080</a> |
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