Interactions gène-environnement dans les troubles psychiatriques (notice n° 1029189)
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|---|---|
| fixed length control field | 04651cam a2200301 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250125172018.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rey, Romain |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Interactions gène-environnement dans les troubles psychiatriques |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2020.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 17 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Les facteurs génétiques qui déterminent la vulnérabilité aux troubles psychiatriques sévères (troubles schizophréniques, dépressifs et bipolaires principalement) ne sont pas suffisants pour provoquer l’apparition du trouble chez un individu donné. L’intervention de facteurs environnementaux est nécessaire pour permettre l’actualisation d’un état de vulnérabilité latent en état pathologique avéré. Pendant des années, facteurs génétiques et facteurs environnementaux ont été considérés comme des entités indépendantes. Pourtant, des résultats récents suggèrent que les troubles psychiatriques dépendent de l’influence synergique de l’environnement et du génotype. Le mécanisme principal par lequel l’environnement influence la survenue d’une affection en interagissant avec une vulnérabilité latente est appelé « interaction gène-environnement ». Les interactions gène-environnement peuvent être envisagées comme la conception actualisée du modèle vulnérabilité-stress. Au cours des dernières années, les progrès en génétique moléculaire ont permis l’identification de différentes interactions gène-environnement par la réalisation d’une première génération d’études ciblant des variants géniques spécifiques (études avec hypothèse a priori), puis plus récemment, par le biais d’une approche pangénomique permettant la réalisation d’études sans hypothèse a priori. La réévaluation du modèle vulnérabilité-stress à la lumière de résultats récents a finalement conduit à la formulation du modèle dit « de réactivité différentielle ». |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Both genetic and environmental factors play important roles in the development of severe mental disorders such as schizophrenia, bipolar disorder, and depression. While environmental risk factors contribute heavily to severe mental disorders, there is also significant evidence of marked individual differences in susceptibility to adverse environmental exposures. The combination of very high heritability and strong environmental factors suggests that severe mental disorders are the result of the interaction between genetic and environmental factors rather than independent main effects. Gene–environment interactions represent a causal mechanism where the genetic factors influence sensitivity to environmental exposures. Over the last twenty years, advances in genetics technology have enabled the study of the interplay between genes and the environment at the level of an individual's measured DNA. The first gene–environment interaction studies were restricted to the exploration of one or more polymorphisms in one or more genes (the so-called gene candidate approach). These genes were selected based on their presumed function in relation to the disorder or the environmental factor of interest. To overcome the limitations of the gene candidate approach, psychiatric research has recently begun to develop genome-wide environment interaction studies to search the entire genome for genetic variants that moderate the effects of the environment on severe mental disorders. While the diathesis-stress model has been the guiding conceptual model for the majority of gene–environment interaction studies, it has recently been thrown into question by the differential susceptibility theory, which suggests that certain individuals are genetically more sensitive to environmental exposures. On the one hand, such individuals may be more prone to developing a psychopathology in response to adverse environments, on the other hand, higher genetic susceptibility may also make them more likely to benefit from favorable environmental situations. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | trouble bipolaire |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | interactions gène-environnement |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | trouble dépressif majeur |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | génétique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | troubles schizophréniques |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | bipolar disorder |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | schizophrenia |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | genetics |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | major depressive disorder |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | gene–environment interaction |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bohec, Anne-Lise |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Revue de neuropsychologie | Volume 12 | 3 | 2020-10-01 | p. 265-272 | 2101-6739 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-de-neuropsychologie-2020-3-page-265?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-de-neuropsychologie-2020-3-page-265?lang=fr&redirect-ssocas=7080</a> |
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