Hematological hypereosinophilia (notice n° 135267)
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|---|---|
| fixed length control field | 02047cam a2200205 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112021258.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ghariani, Inès |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Hematological hypereosinophilia |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2022.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 78 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Hematological disorders are the third-largest cause of hypereosinophilia, after allergic and parasitic disease. Objective: The objective of our study is to show the epidemiological, clinical, biological, and therapeutic characteristics of hematological hypereosinophilia. Patients and methods: This is a retrospective study conducted over a 4-year period (March 2017–March 2021) with 14 patients with hematological hypereosinophilia. Results: Fourteen patients were included (9 women and 5 men). The median age at diagnosis was 55 years. Hematological hypereosinophilia was mainly of clonal etiology. Clinical manifestations were either specific to hypereosinophilia, such as organ damage, or related to the etiology of hypereosinophilia, such as hepatosplenomegaly and lymphadenopathy. Moderate and severe forms were the most commonly reported. Several other quantitative and qualitative abnormalities of the blood picture were reported. Identification of the FIP1L1-PDGFRA fusion gene using molecular biology (RT-PCR) was positive in two patients. Imatinib was the main treatment for clonal forms. Conclusion: Hematological hypereosinophilia is a rare and complex pathology. Our study has confirmed this epidemiological, clinical, biological, and therapeutic heterogeneity and has enabled us to show the contribution of molecular biology in the diagnosis and treatment of hypereosinophilia. |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud, Oumaima |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hamzaoui, Saloua |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Braham, Néjia Jmili |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bekir, Leila |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Annales de Biologie Clinique | 80 | 4 | 2022-07-01 | p. 355-362 | 0003-3898 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/journal-annales-de-biologie-clinique-2022-4-page-355?lang=en">https://shs.cairn.info/journal-annales-de-biologie-clinique-2022-4-page-355?lang=en</a> |
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