Contribution of cytogenetic in the diagnosis of Edwards syndrome: A report on nine cases (notice n° 135632)
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| fixed length control field | 02273cam a2200241 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112021349.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Aouni, Fatima Ezzahra |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Contribution of cytogenetic in the diagnosis of Edwards syndrome: A report on nine cases |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2023.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 8 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Trisomy 18 is a constitutional chromosomal disorder defined by the presence of an extra chromosome 18. The diagnosis is suspected clinically and confirmed by cytogenetic analysis. Genetic counseling for patients’ families is important. The objective of this study is to report our experience in the medical genetics department at the Mohammed VI University Hospital in Oujda of the diagnosis and genetic counseling of trisomy 18 through dysmorphological expertise and cytogenetic analysis. Materials and methods: We report a retrospective descriptive study over a period of four years (2018–2022) of nine patients with polymalformative syndrome suggestive of trisomy 18 who underwent cytogenetic analysis. Results: The median age of patients at diagnosis was 2 days, with a male predominance. The mean maternal age at birth of the patients in our series was 40 years. Consanguinity was found in only one patient. All patients had a typical phenotype of trisomy 18. The postnatal constitutional karyotype showed a homogeneous trisomy 18 in all patients. In our series, only one patient was still alive at the age of 7 months, while the other 8 patients died with a median postnatal survival of 5 days. Conclusion: Through this study, we highlight the contribution of the medical geneticist in the clinical and cytogenetic diagnostic approach of rare chromosomal disorders, in order to provide adequate genetic counseling to families. |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zerrouki, Khawla |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Smaili, Fatimazahra |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ayyad, Anass |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Messaoudi, Sahar |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Babakhouya, Abdeladim |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amrani, Rim |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tajir, Mariam |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Annales de Biologie Clinique | 81 | 3 | 2023-05-01 | p. 304-309 | 0003-3898 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/journal-annales-de-biologie-clinique-2023-3-page-304?lang=en">https://shs.cairn.info/journal-annales-de-biologie-clinique-2023-3-page-304?lang=en</a> |
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