Real-life evaluation of a hypersensitive troponin I measurement on a point-of-care analyzer in an emergency unit (notice n° 136025)
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| fixed length control field | 02600cam a2200217 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112021444.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mottin, Léo |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Real-life evaluation of a hypersensitive troponin I measurement on a point-of-care analyzer in an emergency unit |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2023.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 19 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | European Society of Cardiology (ESC) guidelines introduce the possibility of a rule-in and rule-out algorithm with rapid troponin kinetics to be created in order to manage suspected Non ST-elevation acute coronary syndrome. These recommendations allow the use of point-of-care testing (POCT) systems provided that they have sufficient analytical performance. The aim of our study was to evaluate in real life the feasibility and performance of using a high-sensitivity cardiac troponin I POCT system assay (hs-cTnI, Atellica® VTLi, Siemens) compared to values obtained by a high-sensitivity cardiac troponin T test (hs-cTnT, e602®, Roche) for patients admitted to the emergency department. Analytical verification showed a coefficient of variation below 10% for hs-cTnI. Comparison of both troponins was moderate (r = 0.7). The study included 117 patients with a median age of 65 years, 30% of whom had kidney failure and 36% of whom presented with chest pain. In this study, the hs-cTnT value was more often above the 99th percentile than the hs-cTnl value, even for an age-adjusted 99th percentile hs-cTnT value. The concordance of the results was moderate (Cohen’s Kappa: 0.54), with age remaining the most important explanatory value of discordance. Only hs-cTnT had a predictive value for hospitalization. We did not observe any interpretation discrepancies for patients who had troponin kinetics. This study confirms the feasibility of using a POCT analyzer in the emergency department, provided that it performs a high-sensitivity troponin test. However, some data are missing to be able to use it as part of a rapid algorithm. Finally, the implementation of POCT requires collaboration between biologists and emergency physicians in terms of organization and interpretation of values, for the overall benefit of the patient. |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kassimy, Iliasse Idrissi |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Girot, Hélène |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Leguillon, Romain |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Joly, Luc Marie |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Brunel, Valery |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Annales de Biologie Clinique | 81 | 2 | 2023-03-01 | p. 145-155 | 0003-3898 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/journal-annales-de-biologie-clinique-2023-2-page-145?lang=en">https://shs.cairn.info/journal-annales-de-biologie-clinique-2023-2-page-145?lang=en</a> |
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