Efficacité des probiotiques en prévention de la diarrhée associée aux antibiotiques chez l’enfant en soins ambulatoires (notice n° 1366136)
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fixed length control field | 03212cam a2200313 4500500 |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20250518060854.0 |
041 ## - LANGUAGE CODE | |
Language code of text/sound track or separate title | fre |
042 ## - AUTHENTICATION CODE | |
Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Leblois, Valentin |
Relator term | author |
245 00 - TITLE STATEMENT | |
Title | Efficacité des probiotiques en prévention de la diarrhée associée aux antibiotiques chez l’enfant en soins ambulatoires |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2025.<br/> |
500 ## - GENERAL NOTE | |
General note | 73 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | The prevalence of antibiotic-associated diarrhea (AAD) in the pediatric population is estimated at between 5% and 11%. It is explained by an imbalance in the intestinal microbiota called dysbiosis. Studies suggest that dysbiosis secondary to early antibiotic therapy, responsible for AAD, is also the cause of longer-term effects. According to expert recommendations, probiotics are an appropriate treatment to rebalance the microbiota to prevent dysbiosis and thus cure AAD. These recommendations are based on a Cochrane meta-analysis reviewed in 2019 concluding that the probiotics S. boulardii CNCM I-745 and Lactobacillus rhamnosus GG are effective with a moderate level of evidence according to the GRADE method. However, in 2006, the Haute Autorité de Santé considered that probiotics had an insufficient Medical Benefit (SMR) and proceeded to delist them. Registered in the Rebuild the Evidence Base (REB) project, this trial aims to evaluate the efficacy and tolerance of probiotics in the context of antibiotic-associated diarrhea in children in outpatient care. |
520 ## - SUMMARY, ETC. | |
Summary, etc. | La prévalence de la diarrhée associée aux antibiotiques (DAA) dans la population pédiatrique est estimée entre 5 % et 11 %. Elle serait expliquée par un déséquilibre du microbiote intestinal appelé dysbiose. Des études suggèrent que la dysbiose secondaire à une antibiothérapie précoce, responsable de la DAA, serait également la cause d’effets à plus long terme. Selon les recommandations d’experts les probiotiques seraient un traitement adapté afin de rééquilibrer le microbiote pour prévenir la dysbiose et ainsi guérir la DAA. Ces recommandations s’appuient sur une méta-analyse de la Cochrane revue en 2019 concluant à une efficacité des probiotiques S. boulardii CNCM I-745 et Lactobacillus rhamnosus GG avec un niveau de preuve modéré selon la méthode GRADE. Pourtant, en 2006, la Haute Autorité de Santé a considéré que les probiotiques avaient un Service Médical Rendu (SMR) insuffisant et procédait à leur déremboursement. Inscrit dans le projet Rebuild the Evidence Base (REB), cet essai a pour objectif d’évaluer l’efficacité et la tolérance des probiotiques dans le cadre de la diarrhée associée aux antibiotiques chez l’enfant en soins ambulatoires. |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | antibiotiques |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | diarrhée |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | enfants |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | probiotiques |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | revue de la littérature |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | antibiotics |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | child |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | diarrhea |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | probiotics |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | review |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Louvet, Aude |
Relator term | author |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Boussageon, Rémy |
Relator term | author |
786 0# - DATA SOURCE ENTRY | |
Note | Médecine | 21 | 3 | 2025-05-13 | p. 138-143 | 1777-2044 |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-medecine-2025-03-page-138?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-medecine-2025-03-page-138?lang=fr&redirect-ssocas=7080</a> |
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