Differences in the management of toxic epidermal necrolysis related and unrelated to immune checkpoint inhibitors (notice n° 1413572)
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| fixed length control field | 02675cam a2200313 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250821140539.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Minakawa, Fumika |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Differences in the management of toxic epidermal necrolysis related and unrelated to immune checkpoint inhibitors |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2025.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 8 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | BackgroundThere are currently no reliable biomarkers to predict the occurrence of severe complications and treatment response in patients with toxic epidermal necrolysis (TEN). Immune checkpoint inhibitor-related TEN (irTEN) is much rarer than typical TEN, but mortality rates associated with irTEN are much higher than those for TEN. TEN and irTEN should therefore be managed in a different manner.ObjectivesTo investigate biomarkers that could be used to predict outcomes and therapeutic efficacy associated with irTEN and TEN.Materials & MethodsSeven patients with TEN and two patients with irTEN were included in the study. The seven patients with TEN were treated with varying combinations and sequences of high-dose corticosteroids, intravenous immunoglobulin, pulse corticosteroids and plasma pheresis.ResultsFour of the seven TEN patients developed severe complications, and one patient eventually died due to cytomegalovirus disease. We found that, for TEN, a high neutrophil-to-lymphocyte ratio (NLR) at baseline was associated later onset of severe complications, and a subsequent decrease in NLR after starting immunosuppressive therapy was associated with a beneficial treatment response. In contrast, the opposite was found for the two irTEN patients; a low NLR at baseline and an increase in NLR after starting treatment were associated with poor outcome and a beneficial treatment response, respectively.ConclusionThe NLR may be differentially used as a practical and cost-efficient biomarker to predict treatment response and disease outcomes in patients with TEN and irTEN. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | biomarker |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | immune checkpoint inhibitor |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | neutrophil-to-lymphocyte ratio |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | toxic epidermal necrolysis |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | treatment |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yanagida, Nozomi |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sugiyama, Seiko |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Toi, Yoichiro |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Urakami, Yosuke |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Oka, Daigo |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tanaka, Ryo |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yamamoto, Takenobu |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aoyama, Yumi |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | European Journal of Dermatology | 35 | 3 | 2025-08-04 | p. 224-229 | 1167-1122 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-european-journal-of-dermatology-2025-4-page-224?lang=en&redirect-ssocas=7080">https://shs.cairn.info/revue-european-journal-of-dermatology-2025-4-page-224?lang=en&redirect-ssocas=7080</a> |
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