Bacterial meningitis in newborns (notice n° 1528783)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01610cam a2200157 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20251012013221.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Aujard, Yannick |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Bacterial meningitis in newborns |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2025.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 51 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Bacterial meningitis in newborns is usually secondary to a bacterial translocation from the digestive tract to the bloodstream. The risk of meningeal invasion depends on: 1) specific virulence genes; 2) the bacterial load in the bloodstream; and 3) the level of humoral and cellular immune defenses. The initial bacteremia may also invade brain tissue or the subdural space, causing abscesses and/or empyemas. Lumbar puncture is performed based on clinical and biological risk factors but is not routinely indicated. Empiric antibiotic therapy must be bactericidal. In France, a combination of amoxicillin, cefotaxime, and an aminoglycoside is the most commonly used treatment until the pathogen is identified. Ciprofloxacin, which targets Gram-negative bacteria, and rifampicin, used against GBS, are treatments for brain abscesses. They can be added to the initial antibiotic therapy based on brain MRI results obtained after 5 to 7 days of treatment. The prognosis of bacterial meningitis in newborns is severe, with a mortality rate of 10% and neurological sequelae occurring in 25 to 50% of cases. |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Médecine thérapeutique / Pédiatrie | 26 | 2 | 2025-04-15 | p. 107-116 | 1286-5494 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/journal-medecine-therapeutique-pediatrie-2024-2-page-107?lang=en&redirect-ssocas=7080">https://shs.cairn.info/journal-medecine-therapeutique-pediatrie-2024-2-page-107?lang=en&redirect-ssocas=7080</a> |
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