Kisspeptin level, metabolic and hormonal characteristics in adolescent girls with obesity and menstrual cycle disorders (notice n° 1666468)
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| fixed length control field | 04116cam a2200361 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260222002851.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nikitina, Irina L. |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Kisspeptin level, metabolic and hormonal characteristics in adolescent girls with obesity and menstrual cycle disorders |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2026.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 26 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim. To examine metabolic and hormonal characteristics and their relationships in adolescent girls with obesity with or without menstrual cycle disorders (MCD). Patients and Methods. Forty adolescent girls with obesity (ICD-10 code E66.0) without MCD (median age 15.0 years, IQR 14.0 – 17.0) and 40 girls with obesity and MCD (21 with oligomenorrhea, 19 with secondary amenorrhea, median age 16.0 years, IQR 15.0 – 16.6) participated. Polycystic ovary syndrome (PCOS) was excluded in MCD cases. Tests measured metabolic and hormonal characteristics, including plasma kisspeptin (KP). Results. Girls with MCD had lower serum estradiol, but higher triglycerides, total testosterone (TST), luteinizing hormone (LH), luteinizing-to-follicle-stimulating hormone ratio, and anti-mullerian hormone. They also had higher plasma KP, a reliable MCD predictor. Path analysis identified key relationships and suggested two pathways increasing MCD probability: one linked to increased BMI with mediating leptin and TST, the other to increased KP with mediating LH and TST. Conclusion. Metabolic and hormonal profiles in girls with obesity and MCD resemble those in PCOS. Girls with obesity and MCD should be considered at risk of PCOS. Different pathological pathways associated with MCD in girls with obesity should be considered for treatment. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objectif : examiner les caractéristiques métaboliques et hormonales, et leurs relations, chez les adolescentes obèses avec ou sans troubles du cycle menstruel (TCM). Patients et méthodes : 40 adolescentes obèses (code CIM-10 E 66.0) sans TCM (âge médian 15,0 ans, IQR : 14,0-17,0) et 40 filles obèses avec TCM (21 avec oligoménorrhée, 19 avec aménorrhée secondaire, âge médian 16,0 ans, IQR : 15,0-16,6) ont participé. Le syndrome des ovaires polykystiques (SOPK) a été exclu dans les cas de TCM. Les tests ont mesuré les caractéristiques métaboliques et hormonales, y compris la kisspeptine plasmatique (KP). Résultats : Les filles atteintes de TCM avaient un taux d’œstradiol sérique plus bas, mais des triglycérides, une testostérone totale (TST), une hormone lutéinisante (LH), un ratio LH/hormone folliculostimulante, et une hormone antimüllérienne plus élevés. Ils avaient également des niveaux plasmatiques de KP plus élevés, un prédicteur fiable de la TCM. L’analyse de chemin a identifié des relations clés et a suggéré deux voies augmentant la probabilité de TCM : l’une liée à l’augmentation de l’indice de masse corporelle avec la leptine et la TST comme médiateurs, l’autre corrélée à l’augmentation de KP avec la LH et la TST comme médiateurs. Conclusion : les profils métaboliques et hormonaux chez les filles obèses et atteintes de TCM ressemblent à ceux du SOPK. Les filles obèses et atteintes de TCM doivent être considérées comme à risque de SOPK. Différents chemins pathologiques associés au TCM chez les filles obèses doivent être pris en compte pour le traitement. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | adolescentes |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | analyse de cheminement |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | filles |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | kisspeptine |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | obésité |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | syndrome des ovaires polykystiques |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | troubles du cycle menstruel |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | adolescents |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | girls |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | kisspeptin |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | menstrual cycle disorders |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | obesity |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | path analysis |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | polycystic ovary syndrome |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liskina, Anastasiya S. |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kelmanson, Igor A. |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Sexologies | 34 | 3 | 2026-02-17 | p. 152-166 | 1158-1360 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://stm.cairn.info/revue-sexologies-2025-3-page-152?lang=fr&redirect-ssocas=7080">https://stm.cairn.info/revue-sexologies-2025-3-page-152?lang=fr&redirect-ssocas=7080</a> |
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