P-glycoprotein activity in vivo in older adults: Physiological, pathophysiological, and pharmacokinetic interplay at the blood-brain barrier (notice n° 170871)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01777cam a2200205 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112035054.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Decaix, Théodore |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | P-glycoprotein activity in vivo in older adults: Physiological, pathophysiological, and pharmacokinetic interplay at the blood-brain barrier |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2024.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 52 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | P-glycoprotein (P-gp) is an efflux transporter of xenobiotic and endogenous compounds across the blood-brain barrier (BBB). P-gp plays an essential role by limiting the passage of these compounds into the brain tissue. It is susceptible to drug-drug interactions when interacting drugs are coadministered. The efficiency of P-gp may be affected by the aging process and the development of neurodegenerative diseases. Studying this protein in older adults is therefore highly relevant for all these reasons. Understanding P-gp activity in vivo is essential when considering the physiological, pathophysiological, and pharmacokinetic perspectives, as these aspects seem to be interconnected to some extent. In vivo exploration in humans is based on neuroimaging techniques, which have been improving over recent years. The advancement of exploratory and diagnostic tools is opening up new possibilities for understanding P-gp activity at the blood-brain barrier. |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vrillon, Agathe |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Paquet, Claire |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laprévote, Olivier |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lilamand, Matthieu |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Gériatrie et Psychologie Neuropsychiatrie du Vieillissement | 22 | 2 | 2024-10-10 | p. 137-144 | 2115-8789 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/journal-geriatrie-et-psychologie-neuropsychiatrie-du-vieillissement-2024-2-page-137?lang=en">https://shs.cairn.info/journal-geriatrie-et-psychologie-neuropsychiatrie-du-vieillissement-2024-2-page-137?lang=en</a> |
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