The impact of female infertility on the occurrence of congenital malformations after medically assisted reproduction (notice n° 1719897)
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| fixed length control field | 02657cam a2200289 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260322002025.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Fauque, Patricia |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | The impact of female infertility on the occurrence of congenital malformations after medically assisted reproduction |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2022.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 47 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Do in vitro fertilization (IVF) and intrauterine insemination (IUI) lead to an increased risk of congenital anomalies? This is a major question, which most of the available epidemiological studies unfortunately seem to answer with a “yes.” However, these results are based on data obtained at birth or during the neonatal period, on small populations, and above all without taking into account the possible role of underlying female infertility, a potential confounding factor. Using the French national health system database, we performed a comparative analysis of all singleton births in France over a five-year period (2013–2017), by natural conception (NC), embryo transfer (ET), or IVF. A total of 3,501,495 singleton births were included (3,417,089 NC, 20,218 IUI , and 64,188 ET). The risks of major congenital malformations (ICD-10) were investigated according to mode of conception in multivariate analyses using multiple logistic regression models adjusted for maternal age, primiparity, obesity, smoking, history of hypertension or diabetes, and female infertility. The prevalence of malformations after ET was significantly higher than after NC, with adjusted odds ratios (AOR) of 1.15 and 1.13. The overall risk was similar in the IUI and NC groups (AOR of 1.01). An independent and overall increase in risk was observed in the presence of endometriosis (AOR of 1.16), polycystic ovary syndrome (1.20), or premature ovarian failure (1.52). This study therefore shows that causes of maternal infertility are associated with an increased risk of congenital anomalies, in addition to those associated with IVF. |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | de Mouzon, Jacques |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Devaux, Aviva |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Epelboin, Sylvie |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gervoise-Boyer, |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lévy, Rachel |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Valentin, Morgane |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Viot, Géraldine |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bergère, Marianne |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | De Vienne, Claire |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jonveaux, Philippe |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pessione, Fabienne |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Médecine de la Reproduction | 24 | 1 | 2022-01-01 | p. 91-99 | 2650-8427 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://stm.cairn.info/journal-medecine-de-la-reproduction-2022-1-page-91?lang=en&redirect-ssocas=7080">https://stm.cairn.info/journal-medecine-de-la-reproduction-2022-1-page-91?lang=en&redirect-ssocas=7080</a> |
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