Lésions anopérinéales non fistulisantes de la maladie de Crohn : revue pratique et implications thérapeutiques (notice n° 1727898)
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| fixed length control field | 03550cam a2200397 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260322002936.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Prothe, Carole |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Lésions anopérinéales non fistulisantes de la maladie de Crohn : revue pratique et implications thérapeutiques |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2026.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 15 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Les lésions anopérinéales (LAP) sans fistule dans la maladie de Crohn, bien que fréquentes, sont encore insuffisamment explorées. Contrairement aux fistules et aux abcès, leur prise en charge s’appuie sur des données encore peu standardisées. Leur présentation clinique polymorphe est susceptible de retarder le diagnostic. L’examen clinique constitue une étape incontournable, généralement complétée par une IRM pelvienne pour exclure une fistule ou un abcès. La stratégie thérapeutique repose en premier lieu sur les anti-TNFα, fréquemment associés à des immunosuppresseurs. Les autres biothérapies, notamment les inhibiteurs de Janus Kinase (JAK), sont prometteuses, offrant de nouvelles perspectives thérapeutiques, malgré un niveau faible de preuve par manque de données. La chirurgie est uniquement indiquée dans les formes cicatricielles ou dans les complications dégénératives. De la même manière que les lésions fistulisantes, ce type d’atteinte a un pouvoir de dégénérescence imposant une surveillance, dont les modalités ne sont pas consensuelles. La présente mini-revue propose une synthèse pratique sur le diagnostic, l’évaluation et la prise en charge de ces lésions. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Despite its frequency, non-fistulizing perianal lesions in Crohn’s disease remain underexplored. In contrast to fistulas and abscesses, their management is based on poorly standardized data. Their polymorphic clinical presentation can delay the diagnosis. Clinical examination is essential and should be complemented by pelvic MRI to exclude underlying complications such as fistulas or abscesses. Treatment primarily relies on anti-TNFα agents, often in combination with immunosuppressants. Other biologic therapies, including JAK inhibitors, offer promising prospects, although low level of evidence with limited clinical data on non-fistulizing lesions available. Surgery is reserved for fibrotic lesions or degenerative complications. Long-term follow-up is mandatory due to the risk of anal cancer in chronic cases. This mini-review provides a practical overview of the diagnostic, evaluative, and therapeutic strategies for these underrecognized manifestations of perianal Crohn’s disease. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | anti-TNFα |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | lésions ano-périnéales non fistulisantes |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | maladie de Crohn |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | sténoses |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | ulcération anale |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | anal ulceration |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | anti-TNFα |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Crohn’s disease |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | non fistulizing perianal lésions |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | strictures |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fathallah, Nadia |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Barré, Amélie |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pommaret, Élise |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rentien, Anne-Laure |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Roland, Déborah |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Alam, Amine |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Skoufou, Maria |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Benfredj, Paul |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | de Parades, Vincent |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Hépato-Gastro & Oncologie Digestive | 33 | 1 | 2026-02-10 | p. 20-30 | 2115-3310 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://stm.cairn.info/revue-hepato-gastro-oncologie-digestive-2026-1-page-20?lang=fr&redirect-ssocas=7080">https://stm.cairn.info/revue-hepato-gastro-oncologie-digestive-2026-1-page-20?lang=fr&redirect-ssocas=7080</a> |
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