Les cancers de l’oropharynx liés aux HPV : principales caractéristiques et nouveaux outils virologiques (notice n° 1730163)
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| fixed length control field | 04006cam a2200349 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260322003223.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Malassigné, Victor |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Les cancers de l’oropharynx liés aux HPV : principales caractéristiques et nouveaux outils virologiques |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2026.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 66 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Les carcinomes épidermoïdes de l’oropharynx (OPSCC) associés aux papillomavirus humains (HPV), principalement HPV16, constituent une entité clinique et biologique distincte des OPSCC HPV négatifs. Bien que ces tumeurs présentent généralement un pronostic plus favorable et une meilleure réponse aux traitements standards, environ 10 % à 25 % des patients rechutent après un traitement à visée curative. À ce jour, aucun biomarqueur validé ne permet d’identifier les patients à risque de rechute. Cette revue présente : (i) les bases moléculaires distinguant les OPSCC HPV positifs des OPSCC HPV négatifs ; (ii) l’hétérogénéité des OPSCC HPV positifs, avec un accent particulier sur l’hétérogénéité virale ; et (iii) les nouveaux outils de virologie moléculaire applicables dans le contexte des OPSCC HPV positifs. Ces approches viro-centrées incluent la détection et la quantification de l’ADN tumoral circulant de l’HPV par PCR digitale, ainsi que le séquençage complet du génome viral, outil clé pour l’étude de l’hétérogénéité virale au sein de ces tumeurs. Dans leur ensemble, ces outils offrent des perspectives prometteuses pour améliorer la stratification pronostique et la surveillance personnalisée des patients atteints d’OPSCC HPV positifs. Ils devraient permettre l’identification de biomarqueurs utilisables en pratique clinique courante, ouvrant la voie à des stratégies de désescalade thérapeutique et à un allègement du suivi post-thérapeutique. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinomas (OPSCCs), predominantly driven by HPV16, constitute a clinically and biologically distinct entity from HPV-negative OPSCCs. Although these tumors generally exhibit a more favorable prognosis and improved response to standard treatments, approximately 10-25 % of patients experience recurrence following curative therapy. Currently, no validated biomarkers are available to identify patients at risk of relapse. This review describes: (i) the molecular bases distinguishing HPV-positive from HPV-negative OPSCCs; (ii) the heterogeneity of HPV-positive OPSCCs, with a particular focus on viral heterogeneity; and (iii) emerging molecular virological tools applicable in the context of HPV-positive OPSCCs. These viro-centric approaches include the detection and quantification of circulating tumor HPV DNA using digital PCR, as well as whole viral genome sequencing, which is instrumental for investigating viral heterogeneity within these tumors. Collectively, these tools offer promising perspectives for improving prognostic stratification and personalized monitoring of patients with HPV-positive OPSCCs. They are expected to facilitate the identification of biomarkers suitable for routine clinical use, thereby supporting therapeutic de-escalation strategies and reduced intensity of post-treatment surveillance. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | ADN tumoral circulant |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | biomarqueurs |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | cancer de l’oropharynx |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | HPV |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | séquençage viral |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | biomarkers |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | circulating tumor DNA |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | HPV |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | oropharyngeal cancer |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | viral genome sequencing |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Doghman, Imane |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Balan, Julie |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mirghani, Haitham |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Péré, Hélène |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Veyer, David |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Virologie | 30 | 1 | 2026-03-09 | p. 49-61 | 1267-8694 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://stm.cairn.info/revue-virologie-2026-1-page-49?lang=fr&redirect-ssocas=7080">https://stm.cairn.info/revue-virologie-2026-1-page-49?lang=fr&redirect-ssocas=7080</a> |
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