NK subtype of large granular lymphocytic leukemia (notice n° 174293)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01810cam a2200205 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112035847.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Drillet, Gaëlle |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | NK subtype of large granular lymphocytic leukemia |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2022.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 38 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Large granular lymphocytic leukemias (LGLs) are rare lymphoproliferative syndromes characterized by the clonal expansion of T or NK lymphocytes in 85 and 15% of cases respectively. Interestingly, T- and NK- LGL leukemias share a common pathophysiology and similar clinical and biological presentations. This lymphoproliferative syndrome is characterized by cytopenias and a frequent association with autoimmune diseases or manifestations. It is an indolent disease that in most cases allows for an abstinence-only strategy at diagnosis. However, the majority of patients will require initiation of treatment during follow-up. As NK cells lack a TCR, obtaining evidence of clonality in NK-LGL leukemias is difficult. This is crucial in view of possible reactive expansions in the context of viral infections or dysimmune diseases. The diagnostic approach has been facilitated by the progress made in recent years in the understanding of the pathophysiology and the recent identification of recurrent mutations. In this review, we will discuss the pathophysiology of NK-LGL leukemias and present recent advances in diagnostic strategies before discussing therapeutic management. |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pastoret, Cédric |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Moignet, Aline |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lamy de la Chapelle, Thierry |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marchand, Tony |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Hématologie | 28 | 5 | 2022-09-01 | p. 232-245 | 1264-7527 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/journal-hematologie-2022-5-page-232?lang=en">https://shs.cairn.info/journal-hematologie-2022-5-page-232?lang=en</a> |
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