Bruton’s tyrosine kinase inhibitor treatment in marginal zone lymphoma (notice n° 174746)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01645cam a2200157 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112040004.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Bouabdallah, Kamal |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Bruton’s tyrosine kinase inhibitor treatment in marginal zone lymphoma |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2024.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 85 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Marginal zone lymphomas (MZLs) are a heterogeneous group of rare, typically indolent B-cell lymphoid hematologic disorders where the B-cell receptor (BCR) and its downstream signaling pathways, including Bruton’s tyrosine kinase (BTK), play a central role in the pathophysiology of these hematologic disorders and are major targets for various drug treatments. Targeting the BCR and its downstream kinases such as BTK is critical for the control and inhibition of cell survival. While first-line treatments remain standard, often relying on immunotherapy or immunochemotherapy, relapse treatments have evolved in recent years, with targeted therapies taking the lead, foremost among which are Bruton’s tyrosine kinase inhibitors (BTKis). Ibrutinib is the first of its class to demonstrate efficacy but lacks marketing authorization (MA). Second-generation molecules like zanubrutinib (which has MA but is yet to be covered by the French health insurance system) or acalabrutinib (which does not have MA for this indication) appear to be more effective, offering deeper and more prolonged responses, as well as a more favorable toxicity profile. |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Hématologie | 30 | Special Issue 1 | 2024-06-02 | p. 39-43 | 1264-7527 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/journal-hematologie-2024-Supp1-page-39?lang=en">https://shs.cairn.info/journal-hematologie-2024-Supp1-page-39?lang=en</a> |
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