LncRNA RP11-773H22.4 is upregulated in severe pneumonia and may be a diagnostic and prognostic marker for severe pneumonia (notice n° 1809985)
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| fixed length control field | 02233cam a2200169 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260329001923.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Cao, Yan |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | LncRNA RP11-773H22.4 is upregulated in severe pneumonia and may be a diagnostic and prognostic marker for severe pneumonia |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2024.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 21 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background Pneumonia is becoming increasingly prevalent, and its severity has been continuously escalating, bringing significant damage and stress to people’s lives. The regulatory role of RP11-773H22.4 in the onset and development of severe pneumonia is emerging as an important factor, however, the exact mechanisms controlling its effects have not been fully elucidated. Methods ROC and Kaplan-Meier curves were used to assess the diagnostic and prognostic significance of RP11-773H22.4 in severe pneumonia. qRT-PCR was used to assess the RP11-773H22.4 and miR-1287-5p expression. The CCK-8 was used to assess cell viability. The rate of apoptosis was measured using flow cytometry. The concentration of inflammatory factors was detected using an ELISA kit. The interaction between RP11-773H22.4 and miR-1287-5p was verified by dual luciferase reporter gene assay. Results In individuals afflicted with severe pneumonia, there was an observed up-regulation in RP11-773H22.4 expression and a corresponding decline in miR-1287-5p expression. RP11-773H22.4 demonstrated diagnostic and prognostic significance for severe pneumonia. RP11-773H22.4 augmented the viability of MRC-5 cells with LPS treatment by modulating miR-1287-5p, leading to a reduction in apoptosis and lower levels of inflammatory cytokines. Conclusion RP11-773H22.4 was highly expressed in severe pneumonia and may serve as a diagnostic and prognostic marker for severe pneumonia. miR-1287-5p was downregulated in severe pneumonia, and RP11-773H22.4 participated in the pathogenesis of severe pneumonia by regulating the expression of miR-1287-5p. |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, Feiyan |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Annales de Biologie Clinique | 82 | 2 | 2024-03-01 | p. 187-199 | 0003-3898 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://stm.cairn.info/journal-annales-de-biologie-clinique-2024-2-page-187?lang=en&redirect-ssocas=7080">https://stm.cairn.info/journal-annales-de-biologie-clinique-2024-2-page-187?lang=en&redirect-ssocas=7080</a> |
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