Genetic analysis in miscarriages: What can we learn from products of conception? (notice n° 1920593)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01695cam a2200181 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260329022518.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Dahdouh, Elias M |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Genetic analysis in miscarriages: What can we learn from products of conception? |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2026.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 36 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Recurrent pregnancy loss (RPL) represents a major clinical challenge, often without an identified cause despite a complete medical workup. The recent integration of genetic analyses of products of conception (POC), via chromosomal microarray (CMA) or next-generation sequencing (NGS), has considerably improved the understanding of RPL. They offer an explanation in more than 90% of cases when combined with the standard workup. These technologies make it possible to distinguish embryonic losses linked to chromosomal abnormalities (aneuploidies) from maternal causes (euploidies). This distinction guides the rational use of PGT-A or PGT-SR, useful only in selected cases (advanced maternal age, repeated fetal aneuploidies, infertility, or parental karyotype abnormality). Conversely, the systematic use of PGT-A is inappropriate and not indicated in cases of euploid miscarriages. This comprehensive genetic approach helps to avoid unnecessary treatments, guides more effective management of RPL, and offers reassurance to couples seeking explanations for their loss |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sharara, Fady I |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kutteh, William H |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Médecine de la Reproduction | 27 | 4 | 2026-01-26 | p. 378-381 | 2650-8427 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://stm.cairn.info/journal-medecine-de-la-reproduction-2025-4-page-378?lang=en&redirect-ssocas=7080">https://stm.cairn.info/journal-medecine-de-la-reproduction-2025-4-page-378?lang=en&redirect-ssocas=7080</a> |
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