Controlling effect of ethyl acetate and n-butanol fractions from Punica granatum L. peel on postprandial hyperglycemia in vivo, and their potent inhibitory effect on α-amylase (notice n° 196666)
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| fixed length control field | 01945cam a2200181 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112050000.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Belkacem, N. |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Controlling effect of ethyl acetate and n-butanol fractions from Punica granatum L. peel on postprandial hyperglycemia in vivo, and their potent inhibitory effect on α-amylase |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2023.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 68 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Postprandial hyperglycemia plays an important role in the development of type 2 diabetes and is considered an independent risk factor for cardiovascular diseases. Herbal medicine has been used for many years by different cultures around the world for the treatment of diabetes. Punica granatum is one of the traditional remedies used for that purpose. In this study, we investigated the effects of organic extracts (ethyl acetate and n-butanol) from Punica granatum peel on postprandial hyperglycemia in vivo caused by glucose, sucrose, maltose, or starch loading. Oral administration of Punica granatum peel extracts (400 mg/kg b.w.) markedly lowered plasma glucose levels in fasted normal rats. We examined in vitro whether the organic fractions of Punica granatum peel had an antidiabetic effect by inhibiting α-amylase activity. Ethyl acetate and n-butanol fractions of aqueous/acetone crude extracts displayed a potent inhibitory effect on α-amylase activity (IC50 = 0.85 and 2.13 g/l, respectively). These results suggest that the inhibitory activity of Punica granatum peel extracts may contribute to delaying carbohydrate digestion and glucose absorption, thus improving postprandial hyperglycemia in type 2 diabetes by inhibiting intestinal α-amylase and disaccharidases activity. |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Djaziri, R. |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lahfa, F. |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Phytothérapie | 21 | 1 | 2023-02-01 | p. 41-47 | 1624-8597 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/journal-phytotherapie-2023-1-page-41?lang=en">https://shs.cairn.info/journal-phytotherapie-2023-1-page-41?lang=en</a> |
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