Surmonter la barrière des antivitamines K dans la calciphylaxie (notice n° 2078690)
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| fixed length control field | 03712cam a2200361 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260405004832.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Armi, Sara |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Surmonter la barrière des antivitamines K dans la calciphylaxie |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2026.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 9 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Nous rapportons deux cas de rémission complète de calciphylaxie urémique chez des patients hémodialysés chroniques, malgré la poursuite d’un traitement par antivitamines K (AVK). Ces cas soulignent l’intérêt d’un traitement multimodal, incluant la rhéophérèse comme thérapie prometteuse lorsque l’arrêt des AVK est impossible. Les deux patients ont présenté une calciphylaxie urémique sévère sous AVK en raison d’une valve mécanique mitrale. Ils ont bénéficié d’un traitement multimodal intensif, incluant une hémodialyse quotidienne, du thiosulfate de sodium intraveineux, des calcimimétiques, des chélateurs du phosphate, des analgésiques opioïdes et une évaluation en chirurgie plastique. Un traitement par rhéophérèse a été initié deux fois par semaine pendant quatre mois, période pendant laquelle les AVK ont été maintenus. La fréquence des séances de rhéophérèse a ensuite été progressivement réduite. La guérison complète des plaies a été obtenue en sept mois. Les deux patients ont ensuite bénéficié d’une parathyroïdectomie devant une hyperparathyroïdie tertiaire. À notre connaissance, il s’agit des premiers cas rapportés de rémission complète de calciphylaxie urémique sans interruption des AVK. Cette stratégie de traitement multimodal et multidisciplinaire pourrait représenter une approche efficace chez les patients anticoagulés à haut risque. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | We report two cases of complete remission of uremic calciphylaxis in hemodialysis patients despite continued use of vitamin K antagonists (VKAs). These cases highlight the potential of a multimodal treatment approach including rheopheresis as a promising therapy when VKA discontinuation is not feasible. Both patients presented with severe calciphylaxis while on VKAs for mechanical mitral valve replacement. They received intensive multimodal treatment, including daily hemodialysis, intravenous sodium thiosulfate, calcimimetics, phosphate binders, opioid analgesics, and plastic surgery evaluation. In addition, rheopheresis was initiated twice weekly for four months, during which VKAs were maintained. Rheopheresis frequency was then gradually reduced. Complete wound healing was achieved within seven months. Both patients subsequently underwent parathyroidectomy for tertiary hyperparathyroidism. To our knowledge, these are the first reported cases of full remission of calciphylaxis without VKA discontinuation. A multimodal, multidisciplinary treatment strategy may represent an effective approach for high-risk anticoagulated patients. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | antivitamines K |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | calciphylaxie |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | hémodialyse chronique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | rhéophérèse |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | calciphylaxis |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | chronic hemodialysis |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | rheopheresis |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | vitamin K antagonists |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tailliar, Maxence |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vial, Romain |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bobot, Mickaël |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Brunet, Philippe |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Burtey, Stéphane |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sallée, Marion |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Robert, Thomas |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lefèvre, Flora |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Néphrologie & Thérapeutique | 22. | 1 | 2026-04-03 | p. 71-75 | 1769-7255 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://stm.cairn.info/revue-nephrologie-et-therapeutique-2026-1-page-71?lang=fr&redirect-ssocas=7080">https://stm.cairn.info/revue-nephrologie-et-therapeutique-2026-1-page-71?lang=fr&redirect-ssocas=7080</a> |
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