Pathology and biology of GISTs (notice n° 2081477)
[ vue normale ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 01307cam a2200157 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260405005146.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ngo, Carine |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Pathology and biology of GISTs |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2026.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 50 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract and most often result from activating mutations in the KIT or PDGFRA genes. Their diagnosis relies on morphology and immunohistochemistry, with characteristic expression of KIT (CD117) and DOG1. Tyrosine kinase inhibitors (TKIs), particularly imatinib, have revolutionized GIST management, significantly improving patient survival. The “wild-type” GISTs, lacking KIT or PDGFRA mutations, comprise distinct subtypes, including SDH-deficient GISTs and those harboring BRAF, NF1, or NTRK alterations.The identification of the molecular profile of GISTs is a critical step for optimal patient management, as both the choice of TKI and its dosing directly depend on the tumor mutational status. |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Hépato-Gastro & Oncologie Digestive | 33 | N° Supp 1 | 2026-02-23 | p. 7-15 | 2115-3310 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://stm.cairn.info/journal-hepato-gastro-oncologie-digestive-2026-HS1-page-7?lang=en&redirect-ssocas=7080">https://stm.cairn.info/journal-hepato-gastro-oncologie-digestive-2026-HS1-page-7?lang=en&redirect-ssocas=7080</a> |
Pas d'exemplaire disponible.
Réseaux sociaux