When 2′-O-methylation throws a wrench in HIV-1 reverse transcriptase (notice n° 234427)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01474cam a2200181 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112063605.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Decombe, Alice |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | When 2′-O-methylation throws a wrench in HIV-1 reverse transcriptase |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2024.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 98 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | HIV-1 polymerase, commonly known as reverse transcriptase (RT), catalyzes the critical reaction of reverse transcription by synthesizing a double-stranded DNA copy of the viral RNA genome. During the replication cycle, this synthesized DNA is integrated into the host genome. This entire process is essential for viral replication and serves as a target for several antiviral drugs. Numerous studies in biochemistry and structural biology have provided a better understanding of the function of HIV-1 RT. However, the discovery of epitranscriptomic marks, such as 2′-O-methylations on the HIV-1 RNA genome, raises questions about RT’s ability to copy RNAs adorned with these biochemical modifications. This review focuses on the significance of RT in the viral cycle, its structure and function, and the impact of 2′-O-methylations on its activity and the regulation of replication, particularly in quiescent cells. |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Peersen, Olve |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Decroly, Étienne |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Virologie | 28 | 4 | 2024-07-01 | p. 277-293 | 1267-8694 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/journal-virologie-2024-4-page-277?lang=en">https://shs.cairn.info/journal-virologie-2024-4-page-277?lang=en</a> |
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