Immunological mechanisms involved in the persistence of HIV reservoirs (notice n° 235268)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01666cam a2200205 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112063758.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Espinosa Ortiz, Armando |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Immunological mechanisms involved in the persistence of HIV reservoirs |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2022.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 46 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Antiretroviral therapy (ART) controls viral replication and has dramatically improved the quality of life and life expectancy of people living with HIV (PLHIV). However, almost forty years after the discovery of HIV, there is still no cure; even after years of effective ART, the virus persists in cells, primarily memory CD4 T cells. These cells are a perennial source of infectious viruses, which require people living with HIV to continue ART for life. Research on HIV reservoirs over the past twenty-five years has provided insight into how some infected cells persist for decades without being cleared by ART or by immune responses. HIV “hides” in cells with extended lifespans, which have the capacity to proliferate through diverse mechanisms and which preferentially express several receptors that allow them to remain invisible to the immune system. A better understanding of these mechanisms of persistence is a necessary pre-requisite for the development of therapeutic strategies aimed at eradicating HIV. |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Modica, Alessandro |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fromentin, Rémi |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chomont, Nicolas |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chomont, Nicolas |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Virologie | 26 | 1 | 2022-01-01 | p. 9-22 | 1267-8694 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/journal-virologie-2022-1-page-9?lang=en">https://shs.cairn.info/journal-virologie-2022-1-page-9?lang=en</a> |
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