Actualité dans la biologie des lymphomes folliculaires (notice n° 264015)
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| fixed length control field | 03636cam a2200313 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112074825.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nadel, Bertrand |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Actualité dans la biologie des lymphomes folliculaires |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2019.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 82 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | La pathogenèse du lymphome folliculaire est un processus à plusieurs étapes, complexe, qui se développe au cours de « déraillements » successifs des mécanismes moléculaires et cellulaires rythmant l’ontogénie des lymphocytes B. Cette perturbation progressive des mécanismes de diversification des anticorps, de l’homéostasie des cellules B et de leur dialogue bidirectionnel avec les cellules du microenvironnement, se produit au cours d’une longue phase de croissance asymptomatique préclinique, dans laquelle des clones précurseurs tumoraux se disséminent et établissent des niches prétumorales dans les organes lymphoïdes secondaires. Chez le patient, cette évolution sous-clonale « darwinienne » indolente continue à se développer, sous la pression thérapeutique, sur des cycles de plusieurs années, rythmés par des rechutes de plus en plus fréquentes et réfractaires, ou aboutissant à une transformation en lymphome agressif de mauvais pronostic. Les développements technologiques actuels, permettant le décryptage fonctionnel des cellules tumorales et du microenvironnement, devraient donner rapidement de nouvelles clés pour répondre aux grands enjeux thérapeutiques du lymphome folliculaire : identifier les patients à haut risque dès le diagnostic, comprendre les mécanismes spécifiques de leur pathogenèse et les bases cellulaires et moléculaires des cellules fondatrices menant à la rechute. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The pathogenesis of follicular lymphoma is a complex, multi-stage process that develops during successive “derailments” of molecular and cellular mechanisms punctuating the ontogeny of B lymphocytes. This progressive disruption of the mechanisms of antibody diversification, Homeostasis of B cells and their bidirectional dialogue with microenvironmental cells occurs during a long preclinical asymptomatic growth phase, in which tumor precursor clones disseminate and establish pretrial niches in secondary lymphoid organs. In the patient, this indolent “darwinian” subclonal evolution continues to develop, under therapeutic pressure, over cycles of several years, punctuated by relapses becoming more frequent and refractory, or resulting in a transformation into aggressive lymphoma poor prognosis Current technological developments, allowing the functional deciphering of tumor cells and the microenvironment, should quickly give new keys to answer the major therapeutic issues of follicular lymphoma: identify high-risk patients from diagnosis, understand the specific mechanisms of their pathogenesis and the cellular and molecular bases of the founder cells leading to relapse. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | chaos épigénétique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | biomarqueur de patients à haut risque |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | rechutes liées aux cellules fondatrices |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Cellules fondatrices |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | évolution sous-clonale |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | microenvironnement tumoral |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Founding cells |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | epigenetic chaos |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | founder cell-related relapses |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | tumor microenvironment |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | subclonal evolution |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | biomarker of high-risk patients |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Hématologie | 25 | N° Supp 3 | 2019-11-15 | p. 23-31 | 1264-7527 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-hematologie-2019-HS3-page-23?lang=fr">https://shs.cairn.info/revue-hematologie-2019-HS3-page-23?lang=fr</a> |
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