Cancer colorectal : du consensus moléculaire vers le consensus clinique ? (notice n° 270971)
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|---|---|
| fixed length control field | 02644cam a2200289 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112080431.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Pilati, Camilla |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Cancer colorectal : du consensus moléculaire vers le consensus clinique ? |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2020.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 47 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | RésuméLe cancer colorectal (CCR) a été l’un des premiers cancers à avoir été caractérisé d’un point de vue moléculaire. Initialement répartis en trois groupes moléculaires (instabilité chromosomique, instabilité microsatellitaire et phénotype méthylateur), les CCR font maintenant l’objet d’une classification moléculaire consensuelle transcriptomique qui permet la catégorisation de la plupart des tumeurs en un des quatre sous-types robustes (consensus molecular subtypes, CMS). Ces groupes sont strictement liés à des caractéristiques biologiques, génomiques et épigénetiques, ainsi qu’aux taux de survie. La classification CMS des CCR représente une avancée majeure dans la compréhension des mécanismes moléculaires à l’origine de la transformation maligne des cellules épithéliales coliques, et ouvre la voie dans le développement d’une approche de médecine de précision dans ce cancer. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Colorectal cancer (CRC) was one of the first cancers to be characterized from a molecular point of view. Initially divided into three molecular groups (chromosomal instability, microsatellite instability and methylator phenotype), CRC are now classified under four robust subtypes according to a consensual transcription-based molecular classification (“Consensus Molecular Subtypes”, CMS). These groups are firmly linked to biological, genomic and epigenetic characteristics, as well as survival rates. The CMS classification of CRC represents a major advance in our understanding of the molecular mechanisms behind the malignant transformation of colonic epithelial cells, and opens the way for development of a precision-based approach for this cancer. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | pronostic |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | cancer colorectal |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | consensus |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | traitement |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | classification moléculaire transcriptomique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | consensual transcription-based molecular classification |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | prognostic |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | colorectal cancer |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | treatment |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laurent-Puig, Pierre |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Innovations & Thérapeutiques en Oncologie | Volume 6 | 1 | 2020-01-01 | p. 25-28 | 2431-3203 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-innovations-et-therapeutiques-en-oncologie-2020-1-page-25?lang=fr">https://shs.cairn.info/revue-innovations-et-therapeutiques-en-oncologie-2020-1-page-25?lang=fr</a> |
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