Stress du réticulum endoplasmique et stéatopathies métaboliques (notice n° 271647)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02927cam a2200325 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250112080830.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Lachkar, Floriane |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Stress du réticulum endoplasmique et stéatopathies métaboliques |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2020.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 2 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent pathology associated with obesity. It encompasses a spectrum of hepatic disorders ranging from steatosis to non-alcoholic steatohepatitis (NASH), which may lead to cirrhosis and hepatocellular carcinoma (HCC). Endoplasmic reticulum (ER) stress has been widely involved to drive in NAFLD progression through the activation of the unfolded protein response (UPR). While transient UPR activation can boost hepatic ER functions, its continuous activation upon a chronic ER stress contributes to lipid accumulation, inflammation and hepatocyte death, which are determinant factors for the progression to more severe stages. The aim of this review is to describe the mechanisms through which the UPR can take part in the transition from a healthy to a diseased liver and to report on possible ways of pharmacological manipulation against these pathological mechanisms. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Les stéatopathies métaboliques sont des pathologies en pleine expansion car très associées à l’obésité. Elles englobent un éventail de troubles hépatiques allant de la stéatose à la stéatohépatite non alcoolique (NASH) pouvant conduire à la cirrhose et au carcinome hépatocellulaire (CHC). Le stress du réticulum endoplasmique (RE), à travers l’activation de la voie UPR (Unfolded Protein Response), a été largement impliqué dans le développement et la progression de ces maladies métaboliques hépatiques. Alors que l’activation transitoire de la voie UPR fait partie intégrante de la physiologie hépatique, son activation chronique contribue à la stimulation de voies métaboliques et cellulaires (synthèse des lipides, inflammation, apoptose) qui sont déterminantes dans la progression vers des stades sévères. Le but de cette revue est de décrire comment la voie UPR participe au passage d’un foie sain à un foie malade au cours de l’obésité et d’analyser les perspectives thérapeutiques liées à la manipulation pharmacologique de cette voie. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | UPR |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | obésité |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | lipides |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | inflammation |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | stress du réticulum endoplasmique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | UPR |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | ER stress |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | obesity |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | lipids |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | inflammation |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Papaioannou, Alexandra |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ferré, Pascal |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Foufelle, Fabienne |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Biologie Aujourd'hui | 214 | 1 | 2020-01-01 | p. 15-23 | 2105-0678 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-biologie-aujourdhui-2020-1-page-15?lang=fr">https://shs.cairn.info/revue-biologie-aujourdhui-2020-1-page-15?lang=fr</a> |
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