Accréditation des cryoglobulines : retour d’expérience du CHU de Lyon (notice n° 275526)
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| fixed length control field | 03154cam a2200301 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250117193355.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Dechomet, Magali |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Accréditation des cryoglobulines : retour d’expérience du CHU de Lyon |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2021.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 25 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | RésuméLa recherche et l’identification d’une cryoglobuline sérique constituent un examen biologique couramment prescrit. Cet examen est complexe à accréditer en raison, d’une part, des exigences pré-analytiques très strictes, d’autre part, de l’absence de standardisation entre les laboratoires dans la réalisation des différentes étapes du prélèvement jusqu’au rendu de résultats. La validation de méthode de cette analyse, réalisée pour répondre aux exigences de la norme NF EN ISO 15189, est un processus complexe découpé en trois sous-processus : la recherche de cryoglobuline comprenant la détection et l’isolement du cryoprécipité, le typage par réalisation d’une immunofixation et la quantification de la cryoglobuline par réalisation des dosages d’Immunoglobulines. Ce travail a permis, grâce à l’élaboration d’une matrice des risques prenant en compte l’ensemble des étapes pré-analytiques, analytiques et post-analytiques, de souligner l’importance de la maîtrise technique et de la bonne gestion des équipements critiques. Grâce à cette démarche, le laboratoire s’est également assuré de l’homogénéité des pratiques de rendus de résultats. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Research and identification of a serum cryoglobulin is a current laboratory test. This analysis is complex to accredit due to, firstly, very strict pre-analytical requirements, secondly, lack of standardization between laboratories in carrying out the different phases of sampling until results validation. The method validation of this analysis, carried out to meet requirements of the NF EN ISO 15189 standard, is a complex process divided into three sub-processes: cryoglobulin research including detection and isolation of cryoprecipitate, typing by immunofixation and quantification of cryoglobulin by immunoglobulin assays. This work made it possible, thanks to the development of a risk matrix taking into account all pre-analytical, analytical and post-analytical phases, to stress the importance of technical proficiency and management of critical equipment . With this approach, the laboratory also checked homogeneity of results validation practices. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Cryoglobulines |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | phases pré-analytiques critiques |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | validation de méthode |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | processus complexe |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | method validation |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Cryoglobulins |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | complex process |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | critical pre-analytical phases |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kolopp-Sarda, |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dimet, Isabelle |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lombard, Christine |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Annales de Biologie Clinique | 79 | 2 | 2021-03-01 | p. 190-195 | 0003-3898 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-annales-de-biologie-clinique-2021-2-page-190?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-annales-de-biologie-clinique-2021-2-page-190?lang=fr&redirect-ssocas=7080</a> |
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