Bases moléculaires de l’hyperammoniémie sous asparaginase : de l’efficacité thérapeutique à la toxicité (notice n° 277069)
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|---|---|
| fixed length control field | 03551cam a2200337 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250117194223.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Gallin, Maëlle |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Bases moléculaires de l’hyperammoniémie sous asparaginase : de l’efficacité thérapeutique à la toxicité |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2023.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 5 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Asparaginase is a key molecule in the treatment of acute lymphoblastic leukemia. It has improved response rates to chemotherapy. However, this is not without consequences. Therapeutic efficacy is sometimes achieved at the expense of toxicities that can lead to treatment discontinuation. Among them, patients can develop hyperammonemia which can sometimes be symptomatic leading to neurological disorders that can go as far as hyperammonemic coma or even death. Through a review of the current state of the literature, the objective is to understand the disparity of ammonia values as well as the clinical heterogeneity for a given ammonia concentration. A review of the literature including more than eighty publications was performed. The glutaminase activity of asparaginase seems to play an important role in the development of hyperammonia. At present, no risk factors have been identified for the development of hyperammonemia. On the other hand, the question of the impact of pre-analysis phase arises. Indeed, asparaginase continues to exert its activity in vitro, which leads to an artefactual increase in ammonia. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | L’asparaginase est une molécule-clé dans le traitement des leucémies aigues lymphoblastiques. Elle a permis d’améliorer les taux de réponse aux chimiothérapies. Cependant, ce n’est pas sans conséquence. L’efficacité thérapeutique se retrouve parfois au détriment de toxicités pouvant entraîner l’arrêt du traitement. Parmi elles, les patients peuvent développer une hyperammoniémie qui peut parfois être symptomatique entraînant des troubles neurologiques pouvant aller jusqu’au coma hyperammoniémique voire au décès du patient. À travers une revue de l’état actuel de la littérature, l’objectif est de comprendre la disparité des valeurs d’ammoniémie ainsi que l’hétérogénéité clinique devant une concentration similaire d’ammoniémie. Une revue de la littérature incluant plus de quatre-vingts publications a été réalisée. L’activité glutaminase de l’asparaginase semble jouer un rôle important dans le développement d’hyperammoniémie. Pour autant, aucun facteur de risque n’a été identifié comme impliqué dans l’apparition d’une hyperammoniémie. En revanche, la question de l’impact de la phase pré analytique se pose. En effet, l’asparaginase continue d’exercer son activité in vitro, ce qui entraîne certainement une augmentation artificielle de l’ammoniémie. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | hyperammoniémie |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | biochimie |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | asparaginase |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | biologie clinique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | troubles neurologiques |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | biochemistry |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | hyperammoniaemia |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | neurological disord |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | asparaginase |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | clinical biology |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Damaj, Lena |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gandemer, Virginie |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bendavid, Claude |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Moreau, Caroline |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Annales de Biologie Clinique | 81 | 4 | 2023-08-01 | p. 365-377 | 0003-3898 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-annales-de-biologie-clinique-2023-4-page-365?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-annales-de-biologie-clinique-2023-4-page-365?lang=fr&redirect-ssocas=7080</a> |
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