The mRNA of solute carrier family 22, member 17 (SLC22A17) plays the potential diagnostic and prognostic role in advantage non-small cell lung cancer patients (notice n° 277094)
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| fixed length control field | 04475cam a2200301 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250117194232.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Qin, Wenwen |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | The mRNA of solute carrier family 22, member 17 (SLC22A17) plays the potential diagnostic and prognostic role in advantage non-small cell lung cancer patients |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2023.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 33 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | ObjectiveThis study aims to evaluate the mRNA levels of solute carrier family 22, member 17 (SLC22A17) and its potential clinical value as a diagnostic and prognostic biomarker in non-small cell lung cancer.MethodsThis prospective study measured SLC22A17 mRNA levels in lung cancer and paracancer tissues using quantitative reverse transcription-polymerase chain reaction (PCR). The levels of SLC22A17 mRNA in plasma samples from healthy control subjects and patients with lung cancer were also measured. The association between SLC22A17 mRNA levels in plasma and clinicopathological characteristics was determined. Receiver operating characteristic (ROC) curve analysis was performed to determine the diagnostic value of SLC22A17 in plasma. Survival curve analysis was performed using the Kaplan-Meier method.ResultsSLC22A17 mRNA levels were significantly higher in lung cancer samples than in the paired paracancerous tissues. Plasma SLC22A17 mRNA levels were also significantly higher in patients with lung cancer than in healthy controls. The COX analysis indicated that there was a significant correlation between elevated plasma SLC22A17 mRNA levels and lymph node metastasis, distant metastasis, and TNM stage. Furthermore, the ROC curve analysis demonstrated that plasma SLC22A17 had high diagnostic value. High plasma SLC22A17 mRNA levels are associated with a significantly shorter survival time.ConclusionSLC22A17 is upregulated in lung cancer and may serve as a novel diagnostic and prognostic biomarker |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | ObjectifCette étude vise à évaluer les niveaux d’ARNm du transporteur de soluté de la famille 22, membre 17 (SLC22A17) et sa valeur clinique potentielle en tant que biomarqueur diagnostique et pronostique dans le cancer du poumon non à petites cellules.MéthodesCette étude prospective a mesuré les niveaux d’ARNm du SLC22A17 dans des tissus de cancer du poumon et de paracancer à l’aide d’une transcription inverse quantitative et d’une réaction en chaîne de la polymérase (PCR). Les niveaux d’ARNm SLC22A17 dans les échantillons de plasma de sujets témoins sains et de patients atteints de cancer du poumon ont également été mesurés. L’association entre les niveaux d’ARNm SLC22A17 dans le plasma et les caractéristiques clinico-pathologiques a été déterminée. Une analyse de la courbe ROC (Receiver Operating Characteristic) a été réalisée pour déterminer la valeur diagnostique de SLC22A17 dans le plasma. L’analyse de la courbe de survie a été réalisée à l’aide de la méthode Kaplan-Meier.RésultatsLes niveaux d’ARNm de SLC22A17 étaient significativement plus élevés dans les échantillons de cancer du poumon que dans les tissus paracancéreux appariés. Les niveaux d’ARNm SLC22A17 dans le plasma étaient également significativement plus élevés chez les patients atteints de cancer du poumon que chez les témoins sains. L’analyse COX a montré qu’il existait une corrélation significative entre les niveaux élevés d’ARNm SLC22A17 dans le plasma et les métastases ganglionnaires, les métastases à distance et le stade TNM. En outre, l’analyse de la courbe ROC a démontré que le SLC22A17 plasmatique avait une valeur diagnostique élevée. Des niveaux élevés d’ARNm SLC22A17 dans le plasma sont associés à une durée de survie significativement plus courte.ConclusionSLC22A17 est régulé à la hausse dans le cancer du poumon et peut servir de nouveau biomarqueur diagnostique et pronostique. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | biomarqueur |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | SLC22A17 |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | tissus de cancer du poumon |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | pronostic |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | biomarker |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | prognosis |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | SLC22A17 |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | lung cancer tissues |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ding, Cuimin |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Peng, Fei |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, Ping |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Annales de Biologie Clinique | 81 | 6 | 2023-11-01 | p. 602-609 | 0003-3898 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-annales-de-biologie-clinique-2023-6-page-602?lang=en&redirect-ssocas=7080">https://shs.cairn.info/revue-annales-de-biologie-clinique-2023-6-page-602?lang=en&redirect-ssocas=7080</a> |
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