The role of small dense LDL-C/large buoyant LDL-C ratio as an independent risk factor in patients with type 2 diabetes mellitus and metabolic syndrome (notice n° 277116)
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| fixed length control field | 04778cam a2200481 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250117194245.0 |
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| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Wang, Cui |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | The role of small dense LDL-C/large buoyant LDL-C ratio as an independent risk factor in patients with type 2 diabetes mellitus and metabolic syndrome |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2024.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 62 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | BackgroundDyslipidemia plays a key role in metabolic syndrome (MS), intricately linked to type 2 diabetes mellitus (T2DM).ObjectiveThis study aimed to investigate the differences in low-density lipoprotein cholesterol (LDL-C) subfraction levels between T2DM and T2DM with MS, and identify the risk factors associated with the disease.MethodsA total of 246 individuals diagnosed with T2DM, including 144 T2DM patients with MS, and 147 healthy subjects were recruited. All participants underwent a comprehensive clinical evaluation. Lipoprotein subfraction analysis was performed using the Lipoprint LDL system.ResultsMultivariate logistic regression analysis revealed that several lipid markers, including triglyceride (TG), LDL-C, large buoyant LDL-C (lbLDL-C), small dense LDL-C (sdLDL-C), LDLC2-5, and sdLDL-C/lbLDL-C ratio, were identified as independent risk factors for T2DM. Additionally, TG, sdLDL-C, LDLC-4, LDLC-5, and sdLDL-C/lbLDL-C ratio were found to be independent risk factors for T2DM with MS. Furthermore, the results of the receiver operating characteristic (ROC) curves demonstrated that sdLDL-C, LDLC-4, LDLC-3, and sdLDL-C/lbLDL-C ratio exhibited excellent predictive performance for the risk of T2DM (AUC > 0.9).ConclusionThe sdLDL-C/lbLDL-C ratio emerges as a shared independent risk factor for T2DM and MS complications. Furthermore, sdLDL-C/lbLDL-C ratio, along with LDL-4 and LDL-3, exhibits noteworthy predictive capabilities for T2DM. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | ContexteLa dyslipidémie joue un rôle-clé dans le syndrome métabolique (SM), étroitement lié au diabète de type 2 (DT2).ObjectifCette étude visait à analyser les différences entre les taux de sous-fraction du cholestérol à lipoprotéines de basse densité (C-LDL) chez les personnes atteintes de diabète de type 2 et celles atteintes de SEP, et à identifier les facteurs de risque associés à la maladie.MéthodesAu total, 246 personnes atteintes de DT2, dont 144 patients atteints de DT2 et de SEP, et 147 sujets sains ont été recrutés. Tous les participants ont subi une évaluation clinique complète. L’analyse des sous-fractions de lipoprotéines a été réalisée à l’aide du système Lipoprint LDL.RésultatsUne analyse de régression logistique multivariée a révélé que plusieurs marqueurs lipidiques, notamment les triglycérides (TG), le LDL-C, les particules LDL-C flottantes de grande taille (lbLDL-C), les particules LDL-C de petite taille (sdLDL-C), le LDLC2-5 et le rapport sdLDL-C/lbLDL-C, ont été identifiés comme des facteurs de risque indépendants pour le DT2. En outre, les TG, le sdLDL-C, le LDLC-4, le LDLC-5 et le rapport sdLDL-C/lbLDL-C se sont révélés être des facteurs de risque indépendants pour le DT2 avec la SEP. En outre, les résultats des courbes ROC (Receiver Operating Characteristic) ont montré que le sdLDL-C, le LDLC-4, le LDLC-3 et le rapport sdLDL-C/lbLDL-C présentaient une excellente performance prédictive pour le risque de DT2 (AUC > 0,9).ConclusionLe rapport sdLDL-C/lbLDL-C apparaît comme un facteur de risque indépendant commun pour le DT2 et les complications de la SEP. En outre, le rapport sdLDL-C/lbLDL-C, ainsi que les LDL-4 et LDL-3, présentent des capacités prédictives notables pour le DT2. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | diabète de type 2 |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | LDL-C |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | dyslipidémie |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | syndrome métabolique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | facteur de risque |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | dyslipidemia |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | risk factor |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | metabolic syndrome |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | sdLDL-C/lbLDL-C |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | type 2 diabetes mellitus |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, Yaoze |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lin, Hao |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhu, Yulin |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xu, Xiangdong |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wu, PingPing |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang, Yali |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xu, Ting |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ren, Jian |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xu, Haibo |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dong, Guoyu |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xu, Yue |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jiang, Huihui |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhao, Jiangman |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhai, Yufeng |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Peng, Pei |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zai, Guotian |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Annales de Biologie Clinique | 82 | 2 | 2024-03-01 | p. 174-186 | 0003-3898 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-annales-de-biologie-clinique-2024-2-page-174?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-annales-de-biologie-clinique-2024-2-page-174?lang=fr&redirect-ssocas=7080</a> |
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