Mixtures of chemical pollutants and neurodevelopment in children (notice n° 475845)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01998cam a2200169 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250121064454.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Jeanne, Etiemble |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Mixtures of chemical pollutants and neurodevelopment in children |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2022.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 76 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | To date, only a few epidemiological studies have assessed the links between prenatal and early childhood exposure to mixtures of chemical pollutants and neurodevelopmental disabilities in children. Chemicals in a mixture may have additive, synergistic, or antagonistic effects. Some recent birth cohort studies investigating chemicals and neurodevelopmental effects have applied multipollutant models to the investigation of mixtures. They have examined the overall impact of mixtures, identified the chemicals from mixtures that play a key role in neurotoxicity (such as metals, bisphenols, phthalates, etc.), and investigated their interactive effects. Other domains of the exposome (nutrients, lifestyle, and social factors) may be also implicated in this link to neurodevelopmental effects. Toxicological studies have shown that chemical pollutants share common modes and mechanisms of action, with oxidative stress often described as one of the key events leading to cellular and tissue disruptions at different levels of the brain during critical periods of vulnerability. Epigenetic modifications associated with a number of pollutants (phthalates, bisphenols, pesticides, fine particles, etc.) alter the expression and regulation of genes important for neurodevelopment and contribute to the risk of neurodevelopmental disorders. Advances in knowledge concerning epigenetic markers should prioritize a preventive approach. |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cordier, Sylvaine |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Environnement, Risques & Santé | 21 | 1 | 2022-02-09 | p. 67-79 | 1635-0421 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/journal-environnement-risques-sante-2022-1-page-67?lang=en&redirect-ssocas=7080">https://shs.cairn.info/journal-environnement-risques-sante-2022-1-page-67?lang=en&redirect-ssocas=7080</a> |
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