Origanum essential oils reduce the level of melanin in B16-F1 melanocytes (notice n° 602317)
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| fixed length control field | 02346cam a2200313 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250121154442.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | El Khoury, Rindala |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Origanum essential oils reduce the level of melanin in B16-F1 melanocytes |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2019.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 11 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Hyperpigmentation disorders are considered signs of skin aging and are aesthetically unpleasant. Most active ingredients used against hyperpigmentation disorders predominantly target tyrosinase activity. Objectives: To study the effect of two Origanum essential oils on the melanogenic activity of B16-F1 murine melanocytes. The main component of these oils, carvacrol, was also investigated and a model for anti-melanogenic activity is proposed. Materials and Methods: B16-F1 melanocytes were exposed to different concentrations of essential oils and carvacrol. The level of tyrosinase and melanin was determined using spectrophotometric measurements. Results: Essential oils of Origanum syriacum and Origanum ehrenbergii led to a significant 14% and 17% reduction in melanin level at 40 μg mL-1, respectively. However, neither demonstrated a significant effect on the level of intracellular tyrosinase. The same effects were found for carvacrol which led to a 30% reduction in melanin at 45 μg mL-1. Conclusion: Our results indicate that the oils studied are anti-melanogenic. We propose a mechanism, similar to that for hydroquinone, whereby carvacrol functions as a competitive inhibitor of tyrosinase, thus inhibiting oxidation of tyrosine and causing a deregulation of melanogenesis. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | melanocyte |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | anti-tyrosinase activity |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | carvacrol |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | melanogenesis inhibitor |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | competitive inhibition |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Origanum essential oil |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Michael-Jubeli, Rime |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bakar, Joudi |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dakroub, Hani |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rizk, Toufic |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Baillet-Guffroy, Arlette |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lteif, Roger |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tfayli, Ali |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | European Journal of Dermatology | 29 | 6 | 2019-11-01 | p. 596-602 | 1167-1122 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-european-journal-of-dermatology-2019-6-page-596?lang=en&redirect-ssocas=7080">https://shs.cairn.info/revue-european-journal-of-dermatology-2019-6-page-596?lang=en&redirect-ssocas=7080</a> |
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