Effect of long-term valproic acid therapy on lipid profiles in paediatric patients with epilepsy: a meta-analysis (notice n° 612418)

détails MARC
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fixed length control field 02166cam a2200313 4500500
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control field 20250121162826.0
041 ## - LANGUAGE CODE
Language code of text/sound track or separate title fre
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Authentication code dc
100 10 - MAIN ENTRY--PERSONAL NAME
Personal name Guo, Hong-Li
Relator term author
245 00 - TITLE STATEMENT
Title Effect of long-term valproic acid therapy on lipid profiles in paediatric patients with epilepsy: a meta-analysis
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2022.<br/>
500 ## - GENERAL NOTE
General note 3
520 ## - SUMMARY, ETC.
Summary, etc. Objective Despite the potential role of valproic acid (VPA) in weight gain, the effects of VPA therapy on lipid profiles remain unclear. This study aimed to review the influence of VPA therapy on serum lipid profiles in children with epilepsy. Methods This meta-analysis was conducted on data from PubMed, Web of Science, Cochrane Library, and Embase databases. Case-controlled studies, which assessed the effects of VPA therapy on lipid profiles, were included. All outcomes were recorded as continuous variables, and the effect size was measured. Results VPA therapy was associated with a significant reduction in total cholesterol (mean difference [MD]=-6.34, 95% confidence interval [CI]: -12.30, -0.37, p=0.04) and low-density lipoprotein cholesterol levels (MD = -7.75, 95% CI: -13.48, -2.0, p=0.008). No significant effects were observed regarding the levels of high-density lipoprotein cholesterol and triglycerides. Significance In conclusion, this meta-analysis indicates that VPA therapy causes a decrease in the levels of total cholesterol and low-density lipoprotein cholesterol.
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Topical term or geographic name as entry element total cholesterol (TC)
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Topical term or geographic name as entry element valproic acid
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Topical term or geographic name as entry element triglycerides (TG)
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Topical term or geographic name as entry element high-density lipoprotein cholesterol (HDL-C)
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Topical term or geographic name as entry element low-density lipoprotein cholesterol (LDL-C)
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Dong, Na
Relator term author
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Chen, Feng
Relator term author
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Zeng, Yuan-Yuan
Relator term author
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Hu, Ya-Hui
Relator term author
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Xia, Ying
Relator term author
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Tian, Man
Relator term author
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Lu, Xiao-Peng
Relator term author
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Qiu, Jin-Chun
Relator term author
786 0# - DATA SOURCE ENTRY
Note Epileptic Disorders | Vol 24 | 5 | 2022-05-01 | p. 822-830 | 1294-9361
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://shs.cairn.info/revue-epileptic-disorders-2022-5-page-822?lang=en&redirect-ssocas=7080">https://shs.cairn.info/revue-epileptic-disorders-2022-5-page-822?lang=en&redirect-ssocas=7080</a>

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