Maladie alcoolique du foie : de la physiopathologie aux principales cibles thérapeutiques (notice n° 663124)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02872cam a2200301 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250121193236.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Fakhouri, Hugo |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Maladie alcoolique du foie : de la physiopathologie aux principales cibles thérapeutiques |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2020.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 18 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | La maladie alcoolique du foie regroupe plusieurs entités allant de la stéatose hépatique isolée jusqu’au stade terminal de la fibrose, la cirrhose. Il s’agit d’une maladie au mécanisme physiopathologique complexe faisant intervenir les métabolites toxiques de l’éthanol à l’origine d’un stress oxydatif associé à un état pro-inflammatoire en lien avec une translocation bactérienne et l’activation du système immunitaire. Il existe des interactions complexes entre l’environnement, des facteurs de risques génétiques et le système immunitaire. L’alcool reste à ce jour un problème de santé publique important en lien avec une morbidité-mortalité hépatique et extrahépatique, entraînant un coût non négligeable en dépenses de santé. La compréhension du métabolisme de l’éthanol ainsi que de la physiopathologie de cette maladie permet d’aborder les principales cibles thérapeutiques telles que la corticothérapie associée au N-acétylcystéine dans l’hépatite alcoolique. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Alcoholic liver disease includes several entities ranging from fatty liver to the end stage of fibrosis, the cirrhosis. It is a disease with a complex pathophysiological mechanism involving the toxic metabolites of ethanol, causing oxidative stress associated with a pro-inflammatory state linked to bacterial translocation and activation of the immune system. There are complex interactions between the environment, genetic risk factors and the immune system. Alcohol remains to this day a major public health problem linked to hepatic and extra hepatic morbidity and mortality, resulting in a significant health expenditure. Understanding the metabolism of ethanol and the pathophysiology of this disease makes it possible to address the main therapeutic targets such as corticosteroid therapy associated with N-acetylcysteine in alcoholic hepatitis. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | maladie alcoolique du foie |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | stéatose hépatique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | fibrose hépatique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | hépatoxicité de l’alcool |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | cellule de Kupffer |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | alcoholic liver disease |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | alcohol hepatotoxicity |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | fatty liver |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | Kupffer's cells |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | liver fibrosis |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lemaitre, Caroline |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Hépato-Gastro & Oncologie Digestive | 27 | 6 | 2020-06-01 | p. 576-584 | 2115-3310 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-hepato-gastro-et-oncologie-digestive-2020-6-page-576?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-hepato-gastro-et-oncologie-digestive-2020-6-page-576?lang=fr&redirect-ssocas=7080</a> |
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