Obésité et cancer colorectal (notice n° 663149)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03696cam a2200349 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250121193239.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Quénéhervé, Lucille |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Obésité et cancer colorectal |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2021.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 44 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | L’obésité entraîne une augmentation du risque de cancer colorectal (CCR). Elle semble également avoir un impact négatif sur les complications post-opératoires, l’efficacité des traitements et le pronostic du CCR. La chirurgie bariatrique pourrait diminuer le risque de CCR chez les sujets obèses. Les perturbations métaboliques induites par l’obésité et impliquées dans la cancérogenèse colorectale sont complexes. Différentes hormones, adipokines et médiateurs cellulaires produits au niveau du tissu adipeux contribuent au développement et à la progression tumorale. Les principales voies métaboliques affectées au niveau du tissu adipeux sont celles de l’insuline et des facteurs de croissance IGF et de leurs récepteurs, de la leptine, des adipokines et des œstrogènes ; l’inflammation chronique et les perturbations de l’homéostasie des acides biliaires jouent également un rôle important. Enfin, l’obésité est associée à une diminution significative de la diversité du microbiote intestinal. Ces modifications entraînent une altération de la barrière intestinale, une augmentation des molécules pro-inflammatoires d’origine microbienne. Elles induisent également un remodelage épigénétique et modifient l’expression des gènes dans les cellules épithéliales coliques. Enfin, elles causent des altérations des métabolites microbiens intestinaux qui peuvent causer des dommages à l’ADN et diminuer l’immunité anti-tumorale. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The risk of colorectal cancer (CRC) is increased by obesity. Obesity also seems to have a negative impact on post-operative complications, treatment efficacy and prognosis of CRC. Bariatric surgery may decrease the risk of CRC in obese subjects. The metabolic disorders induced by obesity and involved in colorectal carcinogenesis are complex. Different hormones, adipokins and mediators produced in adipose tissue contribute to tumor development and progression. The main metabolic pathways affected in adipose tissue are those of insulin and IGF growth factors and their receptors, leptin, adipokins and estrogens; chronic inflammation and disturbances of bile acid homeostasis also play an important role. Finally, obesity is associated with a significant decrease in the diversity of the intestinal microbiota. These modifications lead to an alteration of the intestinal barrier, an increase in pro-inflammatory molecules of microbial origin. They also induce epigenetic remodeling and modify gene expression in colonic epithelial cells. Finally, they cause alterations in intestinal microbial metabolites that can cause DNA damage and decrease anti-tumor immunity. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | pronostic |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | chirurgie bariatrique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | cancer colorectal |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | tissu adipeux |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | syndrome métabolique |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | obésité |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | obesity |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | prognostic |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | bariatric surgery |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | metabolic syndrome |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | adipose tissue |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | colorectal cancer |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reboux, Noémi |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noël, Catherine |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Robaszkiewicz, Michel |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Hépato-Gastro & Oncologie Digestive | 28 | 1 | 2021-01-01 | p. 46-53 | 2115-3310 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-hepato-gastro-et-oncologie-digestive-2021-1-page-46?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-hepato-gastro-et-oncologie-digestive-2021-1-page-46?lang=fr&redirect-ssocas=7080</a> |
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