Micro-ARN et cancer colorectal (notice n° 664567)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03518cam a2200505 4500500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250121193714.0 |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | fre |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 10 - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Chautard, Romain |
| Relator term | author |
| 245 00 - TITLE STATEMENT | |
| Title | Micro-ARN et cancer colorectal |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2020.<br/> |
| 500 ## - GENERAL NOTE | |
| General note | 7 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | MicroRNAs (miR) are small single-stranded RNAs. Their role is to post-transcriptionally regulate the expression of target mRNA. They influence the homeostasis of our organism. Dysregulated expression of many miR is involved in pathogenic mechanisms, particularly colorectal cancer (CRC) initiation and development. MiR levels of expression are detected in blood, stool and digestive tissue. Therefore, certain miR can be used as diagnostic and prognostic biomarkers in CRC. Also, some dysregulated miR contribute to drug resistance. Measuring levels of expression of those miR can be used to categorize patients according to their risk of drug-resistance in order to improve their survival. Lastly, artificially modifying miR regulation can be adopted to treat CRC. MiR are key factors in CRC development and their bedside usage is promising and innovative. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Les micro-ARN (miR) sont de petits ARN simple brin. Leur rôle est de réguler la traduction d’ARN messager cible. Ils impactent ainsi le fonctionnement global de notre organisme. Leur dérégulation est impliquée dans un grand nombre de mécanismes pathologiques, notamment dans l’initiation et la progression tumorales colorectales. Il est possible de détecter les fluctuations d’expression des miR dans les tissus digestifs, le sang et les selles. Certains miR ont été identifiés comme des potentiels biomarqueurs diagnostiques et pronostiques du cancer colorectal (CCR). Leurs dérégulations participent également aux mécanismes de résistance à certains médicaments anti-tumoraux. La mesure du niveau d’expression de miR est une piste pour la recherche de biomarqueurs prédictifs de l’efficacité des traitements couramment prescrits dans le CCR. Ils sont également des cibles thérapeutiques potentielles car l’induction pharmacologique de la sur- ou sous-expression de certains miR pourrait être utilisée afin de modifier les caractéristiques des tumeurs et servir de base pour de nouvelles thérapies en oncologie. Les miR représentent des éléments-clés du développement du CCR avec des perspectives d’applications prometteuses et innovantes en pratique clinique. |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | cancer colorectal |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | diagnostic |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | micro-ARN |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | pronostic |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | biomarqueur |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | thérapie |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | cancer colorectal |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | diagnostic |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | micro-ARN |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | pronostic |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | biomarqueur |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | thérapie |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | microRNA |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | colorectal cancer |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | diagnostic |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | biomarker |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | therapeutics |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | prognostic |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | microRNA |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | colorectal cancer |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | diagnostic |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | biomarker |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | therapeutics |
| 690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
| Topical term or geographic name as entry element | prognostic |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ibrahim, Sajida |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Guéguinou, Maxime |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lecomte, Thierry |
| Relator term | author |
| 700 10 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Raoul, William |
| Relator term | author |
| 786 0# - DATA SOURCE ENTRY | |
| Note | Hépato-Gastro & Oncologie Digestive | 27 | 1 | 2020-01-01 | p. 46-53 | 2115-3310 |
| 856 41 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://shs.cairn.info/revue-hepato-gastro-et-oncologie-digestive-2020-1-page-46?lang=fr&redirect-ssocas=7080">https://shs.cairn.info/revue-hepato-gastro-et-oncologie-digestive-2020-1-page-46?lang=fr&redirect-ssocas=7080</a> |
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